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Incidence and mortality of bone cancer among children, adolescents and young adults of Brazil
Balmant, Nathalie Vieira; Reis, Rejane de Souza; Santos, Marceli de Oliveira; Maschietto, Mariana; Camargo, Beatriz de.
  • Balmant, Nathalie Vieira; Instituto Nacional do Cancer. Rio de Janeiro. BR
  • Reis, Rejane de Souza; Fundacao do Cancer. Rio de Janeiro. BR
  • Santos, Marceli de Oliveira; Instituto Nacional do Cancer. Rio de Janeiro. BR
  • Maschietto, Mariana; Centro Nacional de Pesquisa em Energia e Materiais. Laboratorio Nacional de Biociencias. Campinas. BR
  • Camargo, Beatriz de; Instituto Nacional de Cancer. Centro de Pesquisa. Rio de Janeiro. BR
Clinics ; 74: e858, 2019. tab, graf
Article in English | LILACS | ID: biblio-1001832
ABSTRACT

OBJECTIVES:

Bone cancers occur frequently in children, adolescents, and young adults aging 15 to 29 years. Osteosarcoma and Ewing sarcoma are the most frequent subtypes in this population. The aim of this study was to describe incidence and mortality trends of bone cancers among Brazilian children, adolescents and young adults.

METHODS:

Incidence information was obtained from 23 population-based cancer registries. Mortality data were extracted from the Atlas of Cancer Mortality from 1979 to 2013. Specific and adjusted rates per million were analyzed according to gender, morphology and age at diagnosis. Median rates were used as a measure of central tendency. Joinpoint regression was applied to analyze trends.

RESULTS:

Median incidence rates were 5.74 and 11.25 cases per million in children and young adults respectively. Osteosarcoma in the 15-19 years aged group had the highest incidence rates. Stable incidence rates were observed among five registries in 0-14 year's age group. Four registries had a decreased incidence trend among adolescents and young adults. Median mortality rates were 1.22 and 5.07 deaths per million in children and young adults respectively. Increased mortality was observed on the North and Northeast regions. Decreased mortality trends were seen in the South (children) and Southeast (adolescents and young adults).

CONCLUSION:

Osteosarcoma and Ewing Sarcoma are the most incident bone cancers in all Brazilian regions. Bone cancers showed incidence and mortality patterns variation within the geographic regions and across age groups, although not significant. Despite limitations, it is crucial to monitor cancer epidemiology trends across geographic Brazilian regions.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bone Neoplasms / Osteosarcoma Type of study: Incidence study / Prognostic study / Risk factors Limits: Adolescent / Adult / Child / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: South America / Brazil Language: English Journal: Clinics Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Centro Nacional de Pesquisa em Energia e Materiais/BR / Fundacao do Cancer/BR / Instituto Nacional de Cancer/BR / Instituto Nacional do Cancer/BR

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Full text: Available Index: LILACS (Americas) Main subject: Bone Neoplasms / Osteosarcoma Type of study: Incidence study / Prognostic study / Risk factors Limits: Adolescent / Adult / Child / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: South America / Brazil Language: English Journal: Clinics Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Centro Nacional de Pesquisa em Energia e Materiais/BR / Fundacao do Cancer/BR / Instituto Nacional de Cancer/BR / Instituto Nacional do Cancer/BR