Smoking and pulmonary tuberculosis treatment failure: a case-control study / Tabaquismo y fracaso del tratamiento de la tuberculosis pulmonar. Un estudio de casos y controles
J. bras. pneumol
;
45(2): e20180359, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1002442
ABSTRACT
ABSTRACT Objective:
To determine the association between smoking and pulmonary tuberculosis treatment failure.Methods:
This was a case-control study conducted at the Brazilian Institute for Tuberculosis Research in the city of Salvador, Brazil, between 2007 and 2015. We evaluated 284 patients treated for pulmonary tuberculosis, comparing 50 cases of treatment failure with 234 control cases in which the final outcome was cure.Results:
Treatment failure was attributed to smoking and age rather than to gender, income, level of education, alcohol consumption, or marital status. Therefore, even after adjustment for age, the risk of treatment failure was 2.1 times (95% CI 1.1-4.1) higher among the patients with a history of smoking. In addition, being over 50 years of age was found to increase the likelihood of treatment failure by 2.8 times (95% CI 1.4-6.0).Conclusions:
Smoking and aging are both associated with pulmonary tuberculosis treatment failure. Therefore, as part of a tuberculosis control program, health personnel should be prepared to offer strategies to promote smoking cessation and should be more careful with older patients.RESUMEN
RESUMEN Objetivo:
Determinar la asociación entre el tabaquismo y el fracaso del tratamiento de la tuberculosis pulmonar.Metodología:
Este es un estudio caso - control, realizado en el Instituto Brasilero para la Investigación de la Tuberculosis en Salvador, Brasil entre 2007 y 2015. Se compararon 50 casos de fracaso en el tratamiento con 234 controles de pacientes con diagnóstico de tuberculosis pulmonar y con resultado final de cura.Resultados:
Se atribuyó el fracaso del tratamiento al tabaquismo y a la edad, y no al sexo, salario, escolaridad, consumo de alcohol o estado civil. Así, aun después del ajuste por edad, los pacientes con antecedentes de tabaquismo tienen 2,1 (IC95% 1,1-4,1) veces más chance de fracaso en el tratamiento de la tuberculosis. Además, tener una edad mayor de 50 años mostró que la posibilidad de fracaso aumenta 2,8 (IC95% 1,4-6,0) veces más.Conclusiones:
El tabaquismo está relacionado con el fracaso del tratamiento de la tuberculosis pulmonar, así como también el envejecimiento. Por tal motivo, como parte del control de la tuberculosis, el personal de salud debe estar preparado para ofrecer estrategias que promuevan la cesación tabáquica y tener un mayor cuidado con pacientes de grupos etarios superiores.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tuberculosis, Pulmonary
/
Smoking
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
J. bras. pneumol
Journal subject:
Pulmonary Disease (Specialty)
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Oswaldo Cruz/BR
/
Universidade Federal da Bahia/BR
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