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Scorpion toxins targeting Kv1 3 channels: insights into immunosuppression
Oliveira, Isadora S; Ferreira, Isabela G; Alexandre-Silva, Gabriel M; Cerni, Felipe A; Cremonez, Caroline M; Arantes, Eliane C; Zottich, Umberto; Pucca, Manuela B.
  • Oliveira, Isadora S; University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of Physics and Chemistry. Ribeirão Preto. BR
  • Ferreira, Isabela G; University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of Physics and Chemistry. Ribeirão Preto. BR
  • Alexandre-Silva, Gabriel M; Federal University of Roraima. Medical School. Boa Vista. BR
  • Cerni, Felipe A; University of São Paulo. Ribeirão Preto Medical School. Department of Biochemistry and Immunology. Ribeirão Preto. BR
  • Cremonez, Caroline M; University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of Physics and Chemistry. Ribeirão Preto. BR
  • Arantes, Eliane C; University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of Physics and Chemistry. Ribeirão Preto. BR
  • Zottich, Umberto; Federal University of Roraima. Medical School. Boa Vista. BR
  • Pucca, Manuela B; Federal University of Roraima. Medical School. Boa Vista. BR
J. venom. anim. toxins incl. trop. dis ; 25: e148118, 2019. tab, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1002497
ABSTRACT
Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-dependent potassium channels (Kv), including Kv1.3 channels. These channels (Kv1.3) are expressed by various types of tissues and cells, being part of several physiological processes. However, the major studies of Kv1.3 are performed on T cells due its importance on autoimmune diseases. Scorpion toxins capable of acting on potassium channels (KTx), mainly on Kv1.3 channels, have gained a prominent role for their possible ability to control inflammatory autoimmune diseases. Some of these toxins have already left bench trials and are being evaluated in clinical trials, presenting great therapeutic potential. Thus, scorpion toxins are important natural molecules that should not be overlooked in the treatment of autoimmune and other diseases.(AU)
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Full text: Available Index: LILACS (Americas) Main subject: Scorpion Venoms / Potassium Channels / Immunosuppression Therapy Limits: Animals Language: English Journal: J. venom. anim. toxins incl. trop. dis Year: 2019 Type: Article Institution/Affiliation country: Federal University of Roraima/BR / University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Scorpion Venoms / Potassium Channels / Immunosuppression Therapy Limits: Animals Language: English Journal: J. venom. anim. toxins incl. trop. dis Year: 2019 Type: Article Institution/Affiliation country: Federal University of Roraima/BR / University of São Paulo/BR