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First report of treatment failure in a patient with cutaneous leishmaniasis infected by Leishmania (Viannia) naiffi carrying Leishmania RNA virus: a fortuitous combination?
Vieira-Gonçalves, Ricardo; Fagundes-Silva, Giselle Aparecida; Heringer, Júlia Furtado; Fantinatti, Maria; Da-Cruz, Alda Maria; Oliveira-Neto, Manoel Paes; Guerra, Jorge Augusto Oliveira; Gomes-Silva, Adriano.
  • Vieira-Gonçalves, Ricardo; FIOCRUZ. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro. BR
  • Fagundes-Silva, Giselle Aparecida; FIOCRUZ. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro. BR
  • Heringer, Júlia Furtado; FIOCRUZ. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro. BR
  • Fantinatti, Maria; FIOCRUZ. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro. BR
  • Da-Cruz, Alda Maria; FIOCRUZ. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro. BR
  • Oliveira-Neto, Manoel Paes; FIOCRUZ. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro. BR
  • Guerra, Jorge Augusto Oliveira; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Leishmaniose. Manaus. BR
  • Gomes-Silva, Adriano; FIOCRUZ. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro. BR
Rev. Soc. Bras. Med. Trop ; 52: e20180323, 2019. graf
Article in English | LILACS | ID: biblio-1003132
ABSTRACT
Abstract We report the case of a 32-year-old man from Rio de Janeiro, who was infected in the Amazon region of Brazil by Leishmania (Viannia) naiffi. Generally, patients with L. naiffi cutaneous leishmaniasis exhibit a good therapeutic response to either pentavalent antimonials or pentamidine. However, after pentamidine treatment, this patient's infection evolved to therapeutic failure. To understand this clinical outcome, we investigated the presence of the Leishmania RNA virus (LRV) in parasites isolated from the cutaneous lesion; herein, we discuss the possible association between a poor response to pentamidine therapy and the presence of the LRV.
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Full text: Available Index: LILACS (Americas) Main subject: Pentamidine / RNA Viruses / Trypanocidal Agents / Leishmaniasis, Cutaneous / Leishmania Limits: Adult / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: FIOCRUZ/BR / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado/BR

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Full text: Available Index: LILACS (Americas) Main subject: Pentamidine / RNA Viruses / Trypanocidal Agents / Leishmaniasis, Cutaneous / Leishmania Limits: Adult / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: FIOCRUZ/BR / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado/BR