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Miopatías inflamatorias idiopáticas: una mirada actualizada al diagnóstico y el manejo / Idiopathic inflammatory myopathies: a review
Acosta, Ignacio; Matamala, José Manuel; Jara, Paula; Pino, Francisca; Gallardo, Alejandra; Verdugo, Renato.
  • Acosta, Ignacio; Universidad del Desarrollo. Clínica Alemana de Santiago. Departamento Neurología y Psiquiatría. Santiago. CL
  • Matamala, José Manuel; Universidad del Desarrollo. Clínica Alemana de Santiago. Departamento Neurología y Psiquiatría. Santiago. CL
  • Jara, Paula; Universidad del Desarrollo. Clínica Alemana de Santiago. Departamento Neurología y Psiquiatría. Santiago. CL
  • Pino, Francisca; Universidad del Desarrollo. Clínica Alemana de Santiago. Departamento Neurología y Psiquiatría. Santiago. CL
  • Gallardo, Alejandra; Universidad del Desarrollo. Clínica Alemana de Santiago. Departamento de Anatomía Patológica. Santiago. CL
  • Verdugo, Renato; Universidad del Desarrollo. Clínica Alemana de Santiago. Departamento Neurología y Psiquiatría. Santiago. CL
Rev. méd. Chile ; 147(3): 342-355, mar. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1004355
ABSTRACT
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of acquired immune-mediated diseases, which typically involve the striated muscle with a variable involvement of the skin and other organs. Clinically, they are characterized by proximal muscle weakness, elevation of muscle enzymes, myopathic changes on electromyography and an abnormal muscle biopsy. The different IIM have been classified according to their distinctive histopathologic features in dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and immune-mediated necrotizing myopathy (IMNM). Several myositis-specific antibodies are associated with the different phenotypes, as well as with different risk of neoplastic disease and systemic complications. The basis for the treatment of DM, PM, and IMNM is immunosuppression. For IBM there are only symptomatic treatments. Steroids, associated or not with other immunosuppressant drugs, are the first line of treatment. Biologic drugs will allow future individualized therapies. The 10-year survival of DM, PM and IMNM is 62 to 90%. The leading causes of death are neoplastic, lung and cardiac complications. IBM does not impair survival, although it affects the quality of life.
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Full text: Available Index: LILACS (Americas) Main subject: Myositis Type of study: Diagnostic study Limits: Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Chile Institution/Affiliation country: Universidad del Desarrollo/CL

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Full text: Available Index: LILACS (Americas) Main subject: Myositis Type of study: Diagnostic study Limits: Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Chile Institution/Affiliation country: Universidad del Desarrollo/CL