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Hypoglycemia caused by co-secretion of insulin from lung tumor and cardia cancer: first case report
Chen, Yaning; Kang, Yi; Hong, Liu; Yao, Hebin.
  • Chen, Yaning; General Navy Hospital of PLA. Department of Endocrinology. Beijing. CN
  • Kang, Yi; General Navy Hospital of PLA. Department of Endocrinology. Beijing. CN
  • Hong, Liu; General Navy Hospital of PLA. Department of Endocrinology. Beijing. CN
  • Yao, Hebin; General Navy Hospital of PLA. Department of Pathology. Beijing. CN
São Paulo med. j ; 137(1): 100-103, Jan.-Feb. 2019. tab, graf
Article in English | LILACS | ID: biblio-1004736
ABSTRACT
ABSTRACT CONTEXT Non-islet-cell-tumor-induced hypoglycemia (NICTH) is caused on rare occasions by secretion of insulin from tumor cells that are reported to have a single tissue origin. CASE REPORT A 67-year-old male patient had cardia adenocarcinoma and concomitant lung adenocarcinoma with extensive metastases and repeated episodes of intractable hypoglycemia. Immunohistochemical staining for insulin showed that lung adenocarcinoma stained positive and gastric cardia adenocarcinoma stained weakly positive. These results indicate that tumor cells of different tissue origins co-secreted insulin.

CONCLUSIONS:

This is the first report on intractable hypoglycemia due to co-secretion of insulin from two kinds of primary tumor cells in a single patient.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Stomach Neoplasms / Cardia / Adenocarcinoma / Hypoglycemia / Lung Neoplasms Type of study: Diagnostic study Limits: Aged / Humans / Male Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: General Navy Hospital of PLA/CN

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Full text: Available Index: LILACS (Americas) Main subject: Stomach Neoplasms / Cardia / Adenocarcinoma / Hypoglycemia / Lung Neoplasms Type of study: Diagnostic study Limits: Aged / Humans / Male Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: General Navy Hospital of PLA/CN