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Characterization of Lactobacillus fermentum UCO-979C, a probiotic strain with a potent anti-Helicobacter pylori activity
García, Apolinaria; Navarro, Karen; Sanhueza, Enrique; Pineda, Susana; Pastene, Edgar; Quezada, Manuel; Henríquez, Karem; Karlyshev, Andrey; Villena, Julio; González, Carlos.
  • García, Apolinaria; Universidad de Concepción. Facultad de Ciencias Biológicas. Concepción. CL
  • Navarro, Karen; Universidad de Concepción. Facultad de Ciencias Biológicas. Concepción. CL
  • Sanhueza, Enrique; Universidad de Concepción. Facultad de Ciencias Biológicas. Concepción. CL
  • Pineda, Susana; Universidad de Concepción. Facultad de Ciencias Biológicas. Concepción. CL
  • Pastene, Edgar; Universidad de Concepción. Facultad de Farmacia. Concepción. CL
  • Quezada, Manuel; Universidad de Concepción. Facultad de Ciencias Veterinarias. Concepción. CL
  • Henríquez, Karem; Universidad de Concepción. Facultad de Farmacia. Concepción. CL
  • Karlyshev, Andrey; Kingston University. Faculty of Science, Engineering and Computing. London. GB
  • Villena, Julio; Centro de Referencia para Lactobacilos (CERELA-CONICET). Laboratorio de Inmunobiotecnología. Tucumán. AR
  • González, Carlos; Universidad de Concepción. Facultad de Ciencias Biológicas. Concepción. CL
Electron. j. biotechnol ; 25: 75-83, ene. 2017. tab, graf, ilus
Article in English | LILACS | ID: biblio-1008594
ABSTRACT

Background:

Helicobacter pylori is considered as the main risk factor in the development of gastric cancer. In the present study, we performed a detailed characterization of the probiotic properties and the anti-H. pylori activity of a previously isolated lactobacillus strain ­ Lactobacillus fermentum UCO-979C ­ obtained from human gut.

Results:

The strain tolerated pH 3.0; grew in the presence of 2% bile salts; produced lactic acid and hydrogen peroxide; aggregated in saline solution; showed high hydrophobicity; showed high adherence to glass; Caco-2 and gastric adenocarcinoma human cells (AGS) cells; showed an efficient colonization in Mongolian Gerbils; and potently inhibited the growth and urease activity of H. pylori strains. L. fermentum UCO-979C significantly inhibited H. pylori-induced IL-8 production in AGS cells and reduced the viability of H. pylori. With regard to innocuousness, the strain UCO-979C was susceptible to several antibiotics and did not produce histamine or beta-haemolysis in blood agar containing red blood cells from various origins.

Conclusion:

The results demonstrated that L. fermentum UCO-979C is a very good candidate as a probiotic for the protection of humans against H. pylori infections.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Helicobacter pylori / Helicobacter Infections / Probiotics / Limosilactobacillus fermentum / Anti-Bacterial Agents Type of study: Prognostic study / Risk factors Limits: Animals / Humans Language: English Journal: Electron. j. biotechnol Journal subject: Biotechnology Year: 2017 Type: Article / Project document Affiliation country: Argentina / Chile / United kingdom Institution/Affiliation country: Centro de Referencia para Lactobacilos (CERELA-CONICET)/AR / Kingston University/GB / Universidad de Concepción/CL

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Full text: Available Index: LILACS (Americas) Main subject: Helicobacter pylori / Helicobacter Infections / Probiotics / Limosilactobacillus fermentum / Anti-Bacterial Agents Type of study: Prognostic study / Risk factors Limits: Animals / Humans Language: English Journal: Electron. j. biotechnol Journal subject: Biotechnology Year: 2017 Type: Article / Project document Affiliation country: Argentina / Chile / United kingdom Institution/Affiliation country: Centro de Referencia para Lactobacilos (CERELA-CONICET)/AR / Kingston University/GB / Universidad de Concepción/CL