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Altered levels of inhibitory cytokines in patients with thalassemia major and gingival inflammation / Níveis alterados de citocinas inibitórias em pacientes com talassemia major e inflamação gengival
Akcali, Aliye; Kahraman Ceneli, Selda; Meric, Pinar; Nalbantsoy, Ayse; Özçaka, Özgün; Buduneli, Nurcan.
  • Akcali, Aliye; Queen Mary University of London (QMUL). Institute of Dentistry- Barts and The London School of Medicine and Dentistry. Centre for Oral Clinical Research. London. GB
  • Kahraman Ceneli, Selda; Aydin Government Hospital. Department of Haematology. Aydin. TR
  • Meric, Pinar; Ege University. School of Dentistry. Department of Periodontology. Izmir. TR
  • Nalbantsoy, Ayse; Ege University. Faculty of Engineering. Department of Bioengineering. Izmir. TR
  • Özçaka, Özgün; Ege University. School of Dentistry. Department of Periodontology. Izmir. TR
  • Buduneli, Nurcan; Ege University. School of Dentistry. Department of Periodontology. Izmir. TR
Braz. dent. sci ; 22(3): 349-357, 2019. tab, ilus
Article in English | BBO, LILACS | ID: biblio-1009013
ABSTRACT

Objective:

To evaluate local and systemic levels of interleukin-10 (IL-10), IL-33, and tumor necrosis factor alpha (TNF-α) in Thalassemia major (TM) in the presence of gingival inflammation. Material and

Methods:

58 patients (TM, n=29 and systemically healthy controls, n=29) were included to the study. IL-10, IL-33, and TNF-α levels were evaluated in gingival crevicular fluid (GCF), saliva and serum. Clinical periodontal measurements were recorded.

Results:

GCF IL-33 total amounts in TM and gingivitis group were elevated compared to systemically and periodontally healthy group (p=0.01). GCF IL-10, IL33 and TNF-α concentrations were higher in TM and periodontally healthy group than the systemically healthy and gingivitis group (p=0.02, p=0.008, p=0.003). Serum IL-10 levels were elevated in TM and gingivitis compared to the systemically healthy and gingivitis (p=0.0009) and systemically and periodontally healthy (p=0.0007) groups. Serum IL-10 and TNF-α levels in TM and periodontally healthy group were higher than systemically and periodontally healthy group (p=0.01 and p=0.02).

Conclusion:

TM may potentially alter circulating levels of IL-33 and IL-10 and therefore, may affect the degree of periodontal inflammation locally or vice versa. Yet, the underlying mechanism linking the hematologic condition is not clear and deserves further investigation. (AU)
RESUMO

Objetivo:

Avaliar os níveis locais e sistêmicos de interleucina-10 (IL-10), IL-33 e fator de necrose tumoral alfa (TNF-α) na Talassemia Major (TM) na presença de inflamação gengival. Material e

Métodos:

58 pacientes (TM, n = 29 e controles sistemicamente saudáveis, n = 29) foram incluídos no estudo. Os níveis de IL-10, IL-33 e TNF-α foram avaliados em fluido crevicular gengival (FCG), saliva e soro. As medições periodontais clínicas foram registradas.

Resultados:

As quantidades totais de IL-33 no FCG do grupo de TM e gengivite foram elevadas em comparação com o grupo sistemicamente e periodontalmente saudável (p = 0,01). As concentrações de IL-10 , IL-33 e TNF-α do FCG foram maiores no grupo TM e periodontalmente saudáveis do que no grupo sistemicamente saudável e gengivite (p = 0,02, p = 0,008, p = 0,003). Os níveis séricos de IL-10 estavam elevados na TM e gengivite em comparação com os grupos sistemicamente saudável e gengivite (p = 0,0009) e sistemicamente e periodontalmente saudáveis (p = 0,0007). Os níveis séricos de IL-10 e TNF-α no grupo TM e periodontalmente saudáveis foram maiores do que os grupos sistemicamente e periodontalmente saudáveis (p = 0,01 ep = 0,02).

Conclusão:

A TM pode alterar potencialmente os níveis circulantes de IL-33 e IL-10 e, portanto, pode afetar o grau de inflamação periodontal localmente ou vice-versa. No entanto, o mecanismo subjacente que liga a condição hematológica não é claro e merece uma investigação mais aprofundada. (AU)
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Tumor Necrosis Factor-alpha / Interleukin-10 / Beta-Thalassemia / Interleukin-33 / Gingivitis Limits: Humans Language: English Journal: Braz. dent. sci Journal subject: Dentistry / Sa£de Bucal Year: 2019 Type: Article Affiliation country: Turkey / United kingdom Institution/Affiliation country: Aydin Government Hospital/TR / Ege University/TR / Queen Mary University of London (QMUL)/GB

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Full text: Available Index: LILACS (Americas) Main subject: Tumor Necrosis Factor-alpha / Interleukin-10 / Beta-Thalassemia / Interleukin-33 / Gingivitis Limits: Humans Language: English Journal: Braz. dent. sci Journal subject: Dentistry / Sa£de Bucal Year: 2019 Type: Article Affiliation country: Turkey / United kingdom Institution/Affiliation country: Aydin Government Hospital/TR / Ege University/TR / Queen Mary University of London (QMUL)/GB