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Interaction between ascorbic acid and gallic acid in a model of fructose-mediated protein glycation and oxidation
Adisakwattana, Sirichai; Thilavech, Thavaree; Sompong, Weerachat; Pasukamonset, Porntip.
  • Adisakwattana, Sirichai; Chulalongkorn University. Faculty of Allied Health Sciences. Bangkok. TH
  • Thilavech, Thavaree; Chulalongkorn University. Faculty of Allied Health Sciences. Bangkok. TH
  • Sompong, Weerachat; Chulalongkorn University. Faculty of Allied Health Sciences. Bangkok. TH
  • Pasukamonset, Porntip; Kasetsart University. Faculty of Agriculture. Department of Home Economics. Bangkok. TH
Electron. j. biotechnol ; 27: 32-36, May. 2017. tab
Article in English | LILACS | ID: biblio-1010171
ABSTRACT

Background:

Dietary plant-based foods contain combinations of various bioactive compounds such as phytochemical compounds and vitamins. The combined effect of these vitamins and phytochemicals remains unknown, especially in the prevention of diabetes and its complications. The present study aimed to investigate the combined effect of ascorbic acid and gallic acid on fructose-induced protein glycation and oxidation.

Results:

Ascorbic acid (15 µg/mL) and gallic acid (0.1 µg/mL) reduced fructose-induced formation of advanced glycation end products (AGEs) in bovine serum albumin (BSA; 10 mg/mL) by 15.06% and 37.83%, respectively. The combination of ascorbic acid and gallic acid demonstrated additive inhibition on the formation of AGEs after 2 weeks of incubation. In addition, synergistic inhibition on the formation of amyloid cross-ß structure and protein carbonyl content in fructose-glycated BSA was observed. At the same concentration, the combination of ascorbic acid and gallic acid produced a significant additive effect on the 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity.

Conclusion:

Combining natural compounds such as ascorbic acid and gallic acid seems to be a promising strategy to prevent the formation of AGEs.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Ascorbic Acid / Glycation End Products, Advanced / Gallic Acid Language: English Journal: Electron. j. biotechnol Journal subject: Biotechnology Year: 2017 Type: Article Affiliation country: Thailand Institution/Affiliation country: Chulalongkorn University/TH / Kasetsart University/TH

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Full text: Available Index: LILACS (Americas) Main subject: Ascorbic Acid / Glycation End Products, Advanced / Gallic Acid Language: English Journal: Electron. j. biotechnol Journal subject: Biotechnology Year: 2017 Type: Article Affiliation country: Thailand Institution/Affiliation country: Chulalongkorn University/TH / Kasetsart University/TH