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Muscle changes with high-intensity aerobic training in an animal model of renal disease
Togoe, Eliane Barbosa; Silva, Iandara Schettert; Cury, Juliana Loprete; Guarnier, Flavia Alessandra.
  • Togoe, Eliane Barbosa; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development in Midwest Region. Campo Grande. BR
  • Silva, Iandara Schettert; UFMS. Postgraduate Program in Health and Development in Midwest Region. School of Medicine. Campo Grande. BR
  • Cury, Juliana Loprete; Centro Universitário da Grande Dourados. Dourados. BR
  • Guarnier, Flavia Alessandra; Universidade Estadual de Londrina. Department of Pathological Sciences. BR
Acta cir. bras ; 34(5): e201900503, 2019. tab, graf
Article in English | LILACS | ID: biblio-1010873
ABSTRACT
Abstract

Purpose:

To analyze the muscle changes with high-intensity aerobic training (HIAT) in an animal model of renal disease (RD).

Methods:

Twenty one adult Wistar rats were divided into 3 groups healthy sedentary (HS), RD sedentary (RDS), RD aerobic training (RDAT). RDS and RDAT were subjected to unilateral renal ischemia-reperfusion (10 min) and 21days after that, RDAT was subjected to 6 weeks HIAT (swimming). Serum creatinine (Cr) and muscle morphometry (cross-sectional area = CSA) of gastrocnemius were analyzed.

Results:

Cr was higher (p = 0.0053) in RDS (0.82 ± 0.04) than in the others (RDAT 0.55 ± 0.04; HS 0.55 ± 0.04). Morphometric analysis (class interval of CSA in μm2/absolute frequency of muscle fibers in each class) indicated that 50th percentile occurred in HS 7th class (3000.00-3499.00/515), RDS, 8th class (3500.00-3999.00/484), RDAT 5th class (2000.00-2499.00/856). CSA of largest fibers in RDS, RDAT, HS was 9953.00 μm2, 9969.00 μm2,11228.00 μm2, respectively. High frequency of fibers with lower CSA occurred in 4th, 5th, 6th and 7th class in RDA, absence of fibers into 22nd, 23rd classes (RDS and RDAT).

Conclusion:

HIAT in an animal model of RD resulted in increased the number of muscle fibers with smaller CSA.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Physical Conditioning, Animal / Muscle, Skeletal / Renal Insufficiency Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Centro Universitário da Grande Dourados/BR / UFMS/BR / Universidade Estadual de Londrina/BR / Universidade Federal do Mato Grosso do Sul/BR

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Full text: Available Index: LILACS (Americas) Main subject: Physical Conditioning, Animal / Muscle, Skeletal / Renal Insufficiency Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Centro Universitário da Grande Dourados/BR / UFMS/BR / Universidade Estadual de Londrina/BR / Universidade Federal do Mato Grosso do Sul/BR