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Treatment of actinic keratoses and cancerization field of the face and scalp with 0 015% ingenol mebutate gel in Brazilian individuals: safety, tolerability and patients' perspectives
Gameiro, Luiz; Tovo, Luis Fernando Requejo; Sanches Júnior, José Antonio; Aprahamian, Ivan.
  • Gameiro, Luiz; Faculdade de Medicina de Jundiaí. Department of Internal Medicine. Jundiaí. BR
  • Tovo, Luis Fernando Requejo; Faculdade de Medicina de Jundiaí. Discipline of Dermatology. Jundiaí. BR
  • Sanches Júnior, José Antonio; Universidade de São Paulo. Faculdade de Medicina. Department of Dermatology. São Paulo. BR
  • Aprahamian, Ivan; Faculdade de Medicina de Jundiaí. Department of Internal Medicine. Jundiaí. BR
An. bras. dermatol ; 94(3): 313-319, May-June 2019. tab, graf
Article in English | LILACS | ID: biblio-1011106
ABSTRACT
Abstract

Background:

Actinic keratosis (AK) represents a risk of progression to squamous cell carcinoma. Ingenol mebutate gel is a novel therapeutic option for field-directed treatment.

Objectives:

To evaluate the safety, tolerability and patients' perspectives, related to the therapeutic success of managing AKs on the face and scalp with ingenol mebutate gel in Brazilian individuals.

Methods:

This was an observational, retrospective and descriptive study of 68 areas of actinic keratosis on the face and scalp treated with Ingenol mebutate gel involving a total of 37 patients. The drug was applied for three consecutive days on an area of of 25 cm2 and documentation was performed on baseline and days 4, 8, 15, 60 and 180. On day 4, the composite local skin reaction score was calculated. At the end, a questionnaire was applied to evaluate patients' perspectives about the treatment.

Results:

Adherence was 100%, no serious adverse events were recorded and the mean composite local skin reaction score (standard deviation) was 8.61±4.22. The treatment was considered optimum by 75.68% of the patients. Study

limitations:

Calculation of composite local skin reaction score performed only on the fourth day.

Conclusions:

Treatment with ingenol mebutate gel was considered safe and tolerable in Brazilian subjects. Patients had a maximum adherence rate and a great improvement in self-esteem. The results of this research reproduce the findings of the literature.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Dermatologic Agents / Diterpenes / Keratosis, Actinic / Gels Type of study: Observational study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina de Jundiaí/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Dermatologic Agents / Diterpenes / Keratosis, Actinic / Gels Type of study: Observational study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina de Jundiaí/BR / Universidade de São Paulo/BR