American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
An. bras. dermatol
;
94(3): 355-357, May-June 2019. graf
Article
in English
| LILACS
| ID: biblio-1011111
ABSTRACT
Abstract Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acute pancreatitis, pancytopenia, and cardiogenic shock developed rapidly. Deficient renal clearance of meglumine antimoniate can result in severe toxicity, as observed in this case. These side effects are related to cumulative plasma levels of the drug. Therefore, second-line drugs like amphotericin B are a better choice for patients on dialysis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Leishmaniasis, Cutaneous
/
Renal Insufficiency, Chronic
/
Meglumine Antimoniate
/
Antiprotozoal Agents
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual Paulista/BR
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