Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status
Arch. Clin. Psychiatry (Impr.)
; 46(3): 66-71, May.-June 2019. tab
Article
in En
| LILACS
| ID: biblio-1011150
Responsible library:
BR66.1
ABSTRACT
Abstract Background Antimicrobial peptides are components of the innate immune system. Cathelicidin LL-37 plays an important role in antimicrobial defense, exerts proinflammatory effect and strongly affects the immune system functioning. Our recent study revealed that serum concentration of LL-37 is increased in patients with bipolar disorder. Objectives The aim of this study is to re-evaluate serum LL-37 levels in patients with euthymic bipolar disorder and in healthy controls, matched for anthropometric and body composition parameters. Methods 36 adult patients with euthymic bipolar disorder and 68 non-depressed adults were included into the study. Concentration of LL-37 in serum was assessed using ELISA method. Detailed anthropometric measurements, body composition and biochemical analyses were performed. Results There was a statistically significant difference (p = 0.01) in serum LL-37 level between patients with bipolar disorder (4.97 ± 7.98 ng/mL) and control subjects (1.78 ± 2.69 ng/mL). Discussion Results of this study indicate that LL-37 serum level is increased in euthymic bipolar disorder patients. We found that this increase could not be attributed to analyzed anthropometric or body composition parameters.
Key words
Full text:
1
Index:
LILACS
Main subject:
Bipolar Disorder
/
Body Composition
/
Cathelicidins
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Arch. Clin. Psychiatry (Impr.)
Journal subject:
PSIQUIATRIA
Year:
2019
Type:
Article
/
Project document