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Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones
Yildiz, Canan; Altay, Mustafa; Yildiz, Sedat; Çağir, Yavuz; Akkan, Tolga; Ünsal, Yasemin Aydoğan; Beyan, Esin.
Affiliation
  • Yildiz, Canan; Didim State Hospital. Aydin. TR
  • Altay, Mustafa; Sağlik Bilimleri Üniversitesi. Department of Endocrinology and Metabolism. Ankara. TR
  • Yildiz, Sedat; Söke Fehime Faik Kocagöz State Hospital. TR
  • Çağir, Yavuz; Halil Şivgın Çubuk State Hospital. Ankara. TR
  • Akkan, Tolga; Çaldiran District State Hospital. Van. TR
  • Ünsal, Yasemin Aydoğan; Sağlik Bilimleri Üniversitesi. Department of Internal Medicine. Ankara. TR
  • Beyan, Esin; Sağlik Bilimleri Üniversitesi. Department of Internal Medicine. Ankara. TR
Arch. endocrinol. metab. (Online) ; 63(3): 258-264, May-June 2019. tab, graf
Article in En | LILACS | ID: biblio-1011162
Responsible library: BR1.1
ABSTRACT
ABSTRACT Objective The aim of this study is to evaluate and compare arterial stiffness, which is an independent risk indicator for cardiovascular diseases (CVDs), between patients with overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism by antithyroid therapy and healthy volunteers with pulse wave analysis (PWA). Subjects and methods A total of 102 volunteers were included in the study (30 in the overt hyperthyroid group, 28 in the subclinical hyperthyroid group and 14 with euthyroidism by antithyroid therapy and 30 healthy). The arterial stiffness measurements of the participants in the study were performed with the Mobil-O-Graph PWA device (I.E.M. GmBH, Stolberg, Germany), which makes cuff based oscillometric measurement from the brachial artery. Results Systolic blood pressure, pulse rate, central systolic blood pressure, cardiac output, heart rate-corrected augmentation index (Aix@75) and pulse wave velocity (PWV) measurements were significantly higher in the hyperthyroid group than in the control group. The heart rate and PWV in the subclinical hyperthyroid group were significantly higher than the control group. In the euthyroid group, systolic blood pressure, central systolic blood pressure, cardiac output, cardiac index and PWV were found significantly higher than the control group. There was also a negative correlation between Aix@75 and thyroid-stimulating hormone (TSH), and a positive correlation between Aix@75 and free thyroid hormones. Conclusion In our study, we observed that the arterial stiffness was adversely affected by an overt or subclinical increase in thyroid hormones and this correlated with thyroid hormone levels. We recommend that PWV measurement, which is a simple method for detecting CVD risk, can be used in these patients.
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Full text: 1 Index: LILACS Main subject: Thyrotropin / Cardiovascular Diseases / Vascular Stiffness / Hyperthyroidism Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Arch. endocrinol. metab. (Online) Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2019 Type: Article

Full text: 1 Index: LILACS Main subject: Thyrotropin / Cardiovascular Diseases / Vascular Stiffness / Hyperthyroidism Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Arch. endocrinol. metab. (Online) Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2019 Type: Article