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Clinical Significance of Platelet Volume and Other Platelet Parameters in Acute Myocardial Infarction and Stable Coronary Artery Disease / Significado Clínico do Volume Plaquetário e Outros Parâmetros Plaquetários no Infarto Agudo do Miocárdio e Doença Arterial Coronariana Estável
Ding, Liumei; Sun, Lihua; Wang, Feng; Zhu, Liejun; Zhang, Ting; Hua, Fanli.
  • Ding, Liumei; Fudan University. Jinshan Hospital. Clinical Laboratory. Shanghai. CN
  • Sun, Lihua; Zhongshan Hospital. Department of Hematology. Shanghai. CN
  • Wang, Feng; Fudan University. Jinshan Hospital. Clinical Laboratory. Shanghai. CN
  • Zhu, Liejun; Fudan University. Jinshan Hospital. Clinical Laboratory. Shanghai. CN
  • Zhang, Ting; Fudan University. Jinshan Hospital. Clinical Laboratory. Shanghai. CN
  • Hua, Fanli; Zhongshan Hospital. Department of Hematology. Shanghai. CN
Arq. bras. cardiol ; 112(6): 715-719, Jun. 2019. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1011222
ABSTRACT
Abstract

Background:

Platelets are important in the initiation of thrombosis, and their morphological and functional changes are closely related with the occurrence and development of coronary artery thrombosis. Platelet parameters might be valuable in distinguishing between acute myocardial infarction (AMI) and stable coronary artery disease (SCAD).

Objective:

This study was designed to detect and compare changes in platelet parameters, such as mean platelet volume (MPV) in patients with acute myocardial infarction (AMI) and stable coronary artery disease (SCAD) and to investigate their roles in these diseases.

Methods:

Specimen collection Between January 2011 and December 2013, 2 mL of elbow vein blood was drawn from each of 31 patients primarily diagnosed with AMI, 34 SCAD patients and 50 healthy subjects; and placed in EDTA-K2 anticoagulant tubes. Platelet count (PLT), MPV, plateletcrit (PCT), platelet distribution width (PDW), white blood cell (WBC) and neutrophil (NEU) counts were determined using an STKS automated hematology analyzer (Beckman Courter).

Results:

Compared with the control group, MPV levels were significantly higher in the AMI and SCAD groups (p < 0.05), while PLT was significantly lower (p < 0.05).

Conclusion:

These results suggest that MPV and other related parameters have a certain value in the diagnosis of SCAD and AMI.
RESUMO
Resumo Fundamento As plaquetas são importantes no início da trombose e suas alterações morfológicas e funcionais estão intimamente relacionadas com a ocorrência e o desenvolvimento de trombose da artéria coronária. Os parâmetros plaquetários podem ser valiosos na distinção entre infarto agudo do miocárdio (IAM) e doença arterial coronariana estável (DACE).

Objetivo:

O objetivo desse estudo foi detectar e comparar alterações nos parâmetros plaquetários, como o volume plaquetário médio (VPM) em pacientes com infarto agudo do miocárdio (IAM) e doença arterial coronariana estável (DACE) e investigar seu papel nessas doenças.

Métodos:

Coleta de amostras Entre janeiro de 2011 e dezembro de 2013, foram retirados 2 mL de sangue da veia do antebraço de cada um dos 31 pacientes diagnosticados principalmente com IAM, 34 pacientes com DACE e 50 indivíduos saudáveis; e colocado em tubos com anticoagulante EDTA-K2. As contagens de plaquetas (PQT), VPM, massa total de plaquetas (MTP), Amplitude de Distribuição de Plaquetas (PDW, do inglês platelet distribution width), contagem de glóbulos brancos (WBC, do inglês white blood cells) e neutrófilos (NEU) foram determinadas utilizando-se um analisador de hematologia automatizado STKS (Beckman Courter).

Resultados:

Comparado com o grupo controle, os níveis de VPM foram significativamente maiores nos grupos IAM e DACE (p < 0,05), enquanto os níveis de PQT foram significativamente menores (p < 0,05).

Conclusão:

Esses resultados sugerem que o VPM e outros parâmetros associados têm um certo valor no diagnóstico de DACE e IAM.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Platelet Count / Coronary Artery Disease / Mean Platelet Volume / Myocardial Infarction Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Language: English / Portuguese Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Fudan University/CN / Zhongshan Hospital/CN

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Full text: Available Index: LILACS (Americas) Main subject: Platelet Count / Coronary Artery Disease / Mean Platelet Volume / Myocardial Infarction Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Language: English / Portuguese Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Fudan University/CN / Zhongshan Hospital/CN