Telomere length and childhood trauma in Colombians with depressive symptoms
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
41(3): 194-198, May-June 2019. tab
Article
in English
| LILACS
| ID: biblio-1011493
ABSTRACT
Objective:
Childhood trauma and telomere length (TL) are important risk factors for major depressive disorder. We examined whether there was an association between childhood trauma and TL in a sample of Colombians who were assessed for depressive symptoms.Methods:
We applied the Center for Epidemiologic Studies Depression scale, the Patient Health Questionnaire-9, the Hospital Anxiety and Depression scale and the Childhood Trauma Questionnaire to 92 Colombian subjects (mean age = 21). TL was measured with quantitative PCR. Spearman's correlation coefficient (rs) was used to analyze the relationship between childhood trauma scores and TL.Results:
We found a significant correlation between TL and sexual abuse scores (rs = 0.428, p = 0.002) in individuals with higher depressive symptom scores.Conclusion:
This is the first report of a significant association between TL and sexual abuse in a Latin American sample and provides additional evidence about the role of childhood trauma and TL in neuropsychiatric disorders.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Child Abuse
/
Telomere
/
Depressive Disorder, Major
/
Telomere Shortening
Type of study:
Diagnostic study
/
Qualitative research
/
Risk factors
Limits:
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Colombia
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2019
Type:
Article
Affiliation country:
Colombia
/
Spain
Institution/Affiliation country:
Universidad Antonio Nariño/CO
/
University of Barcelona/ES
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