Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
41(4): 289-296, July-Aug. 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1011508
ABSTRACT
Objective:
To evaluate whether exposing rats to individual or combined environmental stressors triggers endophenotypes related to mood and anxiety disorders, and whether this effect depends on the nature of the behavior (i.e., innate or learned).Methods:
We conducted a three-phase experimental protocol. In phase I (baseline), animals subjected to mixed schedule of reinforcement were trained to press a lever with a fixed interval of 1 minute and a limited hold of 3 seconds. On the last day of phase I, an open-field test was performed and the animals were divided into four experimental groups (n=8/group). In phase II (repeated stress), each group was exposed to either hot air blast (HAB), paradoxical sleep deprivation (PSD) or both (HAB+PSD group) on alternate days over a 10-day period. Control group animals were not exposed to stressors. In phase III (post-stress evaluation), behavior was analyzed on the first (short-term effects), third (mid-term effects), and fifth (long-term effects) days after repeated stress.Results:
The PSD group presented operant hyperactivity, the HAB group presented spontaneous hypoactivity and anxiety, and the HAB+PSD group presented spontaneous hyperactivity, operant hypoactivity, impulsivity, loss of interest, and cognitive impairment.Conclusion:
A combination of environmental stressors (HAB and PSD) may induce endophenotypes related to bipolar disorder.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Stress, Psychological
/
Behavior, Animal
/
Bipolar Disorder
/
Cognition Disorders
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Departamento de Fisiologia e Farmacologia/BR
/
Núcleo de Pesquisa e Desenvolvimento de Medicamentos/BR
/
Universidade Federal do Ceará (UFC)/BR
Similar
MEDLINE
...
LILACS
LIS