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Circulating high mobility group box-1 and toll-like receptor 4 expressions increase the risk and severity of epilepsy
Kan, Minchen; Song, Lihong; Zhang, Xueqiang; Zhang, Jing; Fang, Pingping.
  • Kan, Minchen; HanDan Central Hospital. Department of Neurology. Handan. CN
  • Song, Lihong; HanDan Central Hospital. Medical Department. Handan. CN
  • Zhang, Xueqiang; HanDan Central Hospital. Handan. CN
  • Zhang, Jing; HanDan Central Hospital. Department of Neurology. Handan. CN
  • Fang, Pingping; HanDan Central Hospital. Department of Neurology. Handan. CN
Braz. j. med. biol. res ; 52(7): e7374, 2019. tab, graf
Article in English | LILACS | ID: biblio-1011596
ABSTRACT
This study aimed to investigate the association of serum high-mobility group box-1 (HMGB1) and toll-like receptor 4 (TLR4) expressions with the risk of epilepsy as well as their correlations with disease severity and resistance to anti-epilepsy drugs. One hundred and five epilepsy patients and 100 healthy controls (HCs) were enrolled in this case-control study, and serum samples were collected from all participants to assess the HMGB1 and TLR4 expressions by enzyme-linked immunosorbent assay (ELISA). Both serum HMGB1 (P<0.001) and TLR4 (P<0.001) expressions were higher in epilepsy patients than in HCs, and they displayed good predictive values for risk of epilepsy. Moreover, HMGB1 was positively correlated with TLR4 level (r=0.735, P<0.001). HMGB1 and TLR4 levels were both elevated in patients with an average seizure duration >5 min compared to patients with a seizure duration ≤5 min (P=0.001 and P=0.014, respectively). Also, HMGB1 and TLR4 were increased in patients with seizure frequency >3 times per month compared to patients with seizure frequency ≤3 times per month (both P=0.001). In addition, HMGB1 and TLR4 expressions were higher in intractable cases compared to drug-responsive cases (P<0.001). In conclusion, both HMGB1 and TLR4 expressions were correlated with increased risk and severity of epilepsy and their level was higher in patients resistant to anti-epilepsy drugs.
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Full text: Available Index: LILACS (Americas) Main subject: HMGB1 Protein / Epilepsy / Toll-Like Receptor 4 / Anticonvulsants Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: HanDan Central Hospital/CN

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Full text: Available Index: LILACS (Americas) Main subject: HMGB1 Protein / Epilepsy / Toll-Like Receptor 4 / Anticonvulsants Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: HanDan Central Hospital/CN