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Reproducibility of carotid ultrasound measurements in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) at baseline
Santos-Neto, P J; Sena-Santos, E H; Meireles, D P; Santos, I S; Bensenor, I M; Lotufo, P A.
  • Santos-Neto, P J; Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo. BR
  • Sena-Santos, E H; Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo. BR
  • Meireles, D P; Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo. BR
  • Santos, I S; Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo. BR
  • Bensenor, I M; Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo. BR
  • Lotufo, P A; Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo. BR
Braz. j. med. biol. res ; 52(8): e8711, 2019. tab
Article in English | LILACS | ID: biblio-1011600
ABSTRACT
Carotid artery assessment by ultrasound is a non-invasive evaluation of subclinical atherosclerosis and a predictor of cardiovascular events. However, ultrasound examinations are operator-dependent. In the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), ultrasound images have been acquired from more than 10,000 participants. In this article, we describe the reproducibility of carotid intima-media thickness (CIMT), carotid plaque detection, and carotid plaque score (defined as the number of arterial sites with plaques) using ELSA-Brasil protocol, in a subset of 118 participants. Two board-certified radiologists and a trained technician read carotid images. We calculated intra- and inter-observer intraclass correlation (ICC) for CIMT values. We also present kappa coefficients for plaque detection and weighted kappa coefficients for carotid plaque score. Participants were aged 58.2±6.6 years, and 60 (50.8%) were men. For common carotid artery CIMT measurements, intra- and inter-observer ICC values were very good to excellent, ranging from 0.90 (95% confidence interval [95%CI] 0.72-0.95) to 0.98 (95%CI 0.97-0.99). For carotid plaque, intra- (0.96 [95%CI 0.96-0.96]) and inter- (0.99 [95%CI 0.99-0.99]) observer weighted kappa coefficients were very good. Intra- and inter-observer Kappa coefficients for the presence of plaques by site were good to very good, ranging from 0.69 to 1.00. In conclusion, we found very good reproducibility for carotid plaque score and CIMT measurements in the ELSA-Brasil at baseline. These results are comparable to the best findings from similar large cohorts that analyzed carotid ultrasound data.
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Full text: Available Index: LILACS (Americas) Main subject: Carotid Arteries / Atherosclerosis / Plaque, Atherosclerotic / Carotid Intima-Media Thickness Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Carotid Arteries / Atherosclerosis / Plaque, Atherosclerotic / Carotid Intima-Media Thickness Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR