Association between BDNF G196A (Val66Met) polymorphism and cognitive impairment in patients with Parkinson's disease: a meta-analysis
Braz. j. med. biol. res
;
52(8): e8443, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1011604
ABSTRACT
Brain-derived neurotrophic factor (BDNF) is widely expressed in the central nervous system and prolongs the survival of dopaminergic neurons in the substantia nigra. Several studies have recently investigated the association between BDNF G196A (Val66Met), a single nucleotide polymorphism influencing cognitive processes, and cognitive impairment in Parkinson's disease (PD), but with contradictory findings. Thus, this meta-analysis was performed to clarify the possible association. Relevant studies were identified by a systematic search of PubMed, Embase, and China National Knowledge Infrastructure (CNKI) databases. The strength of the association was evaluated using crude odds ratios and 95% confidence interval. Finally, six studies involving 532 cases and 802 controls were included. Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cognitive impairment in PD, especially in Caucasian populations. In conclusion, BDNF G196A (Val66Met) is confirmed to be a risk factor for cognitive impairment in PD.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Parkinson Disease
/
Brain-Derived Neurotrophic Factor
/
Cognitive Dysfunction
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2019
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University/CN
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