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Toxicity assessment of the alcoholic leaves extract of Reinwardtia indica
Upadhyay, Prabhat; Shukla, Rashmi; Tiwari, Kavindra Nath; Dubey, G P; Mishra, Sunil Kumar.
  • Upadhyay, Prabhat; Banaras Hindu University. Department of Pharmacology. Institute of Medical Sciences. Varanasi. IN
  • Shukla, Rashmi; Banaras Hindu University. Department of Medicinal Chemistry. Institute of Medical Sciences. Varanasi. IN
  • Tiwari, Kavindra Nath; MMV Banaras Hindu University Varanasi. Department of Botany. Varanasi. IN
  • Dubey, G P; Banaras Hindu University. Institute of Medical Sciences. Varanasi. IN
  • Mishra, Sunil Kumar; Banaras Hindu University. Department of Pharmaceutical, Engineering and Technology. Indian Institute of Technology. Varanasi. IN
Braz. J. Pharm. Sci. (Online) ; 55: e18224, 2019. tab, graf, ilus
Article in English | LILACS | ID: biblio-1011647
ABSTRACT
The present study aimed to evaluate the safety of the alcoholic leaves extract of Reinwardtia indica in Charles foster rats through an acute and sub-acute oral administration.For assessment of acute oral toxicity test, ratswere orally treated with single dose of the alcoholic leaves extract of Reinwardtia indica at the doses of 50, 250, 500, 1000 2000 and 5000 mg/kg. In sub-acute toxicity study, using the OECD guidelines no. 407, the extract was administered at the doses of 50, 250, 500, 1000, 2000 mg/kg/day for 28 consecutive days and at the dose of 2000 mg/kg satellite group also used for 6 weeks.In acute toxicity above mentioned doses neither showed mortality nor exterior signs of toxicity. In sub-acute, study no significant changes found in haematological and biochemical level ofthe treated rat after 14 days and 28 days in comparison to control. The histopathology of rat brain, kidney, liver, and heart also showed the no cellular changes after extract treated rat.The alcoholic leaves extract of Reinwardtia indica was found non-toxic in single drug dose administration up to 5000 mg/kg (acute study) and in sub-acute administration up to 2000 mg/kg.
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Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Plant Leaves / Linaceae Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2019 Type: Article Affiliation country: India Institution/Affiliation country: Banaras Hindu University/IN / MMV Banaras Hindu University Varanasi/IN

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Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Plant Leaves / Linaceae Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2019 Type: Article Affiliation country: India Institution/Affiliation country: Banaras Hindu University/IN / MMV Banaras Hindu University Varanasi/IN