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Antidiabetic activity evaluation of Onobrychis species on alloxan-induced diabetic mice
Ozbek, Hanefi; Acikara, Ozlem Bahadir; Oz, Burcin Ergene; Ozbilgin, Serkan; Kirmizi, Neriman Ipek; Ozrenk, Bade Cevriye; Tekin, Mehmet; Saltan, Gulcin.
  • Ozbek, Hanefi; Istanbul Medipol University. Faculty of Medicine. Department of Pharmacology. Istanbul. TR
  • Acikara, Ozlem Bahadir; Ankara University. Faculty of Pharmacy. Department of Pharmacognosy. Ankara. TR
  • Oz, Burcin Ergene; Ankara University. Faculty of Pharmacy. Department of Pharmacognosy. Ankara. TR
  • Ozbilgin, Serkan; Ankara University. Faculty of Pharmacy. Department of Pharmacognosy. Ankara. TR
  • Kirmizi, Neriman Ipek; Istanbul Medipol University. IMU Vocational School. Department of Occupational Health and Safety. Istanbul. TR
  • Ozrenk, Bade Cevriye; Istanbul Medipol University. IMU Vocational School. Department of Occupational Health and Safety. Istanbul. TR
  • Tekin, Mehmet; Trakya University. Faculty of Pharmacy. Department of Pharmaceutical Botany. Sivas. TR
  • Saltan, Gulcin; Ankara University. Faculty of Pharmacy. Department of Pharmacognosy. Ankara. TR
Braz. J. Pharm. Sci. (Online) ; 55: e18157, 2019. tab, graf
Article in English | LILACS | ID: biblio-1011648
ABSTRACT
In the current study, four Onobrychis species, O. albiflora Hub.-Mor., O. argyrea Boiss. subsp. argyrea Boiss., O. galegifolia Boiss., and O. tournefortii (Willd.) Desv. were collected from Anatolia to be evaluated for their antidiabetic activities. Methanol water extracts of the aerial parts were used for experiments. An alloxan-induced diabetic mice test model was used. Phytochemical analysis of the tested extracts was investigated using the HPLC method. The highest activity was observed with treatment of O. albiflora aerial part extract. Significant decrements were detected in the blood glucose levels as follows 180.83±47.48 and 252.83±50.47mg/dL at 100 mg/kg and 200 mg/kg doses of O. albiflora, respectively, when compared to the isotonic saline solution control group, eliciting a blood glucose level of 494.20±27.32. Among the tested standard compounds, rutin and isoquercetin were detected in the examined species. The highest amount of rutin (1.1981±0.0017%) and isoquercetin (0.7318±0.0197%) were found in O. albiflora and O. argyrea subsp. argyrea, respectively. Antidiabetic activities of the tested Onobrychis species seem to indicate a possible correlation with their rutin and isoquercetin contents. Therefore, rutin and isoquercetin may be the antidiabetic compounds that contribute to the antidiabetic activity of the tested Onobrychis species.
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Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Hypoglycemic Agents / Fabaceae Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2019 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ankara University/TR / Istanbul Medipol University/TR / Trakya University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Hypoglycemic Agents / Fabaceae Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2019 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ankara University/TR / Istanbul Medipol University/TR / Trakya University/TR