p38MAPK plays a pivotal role in the development of acute respiratory distress syndrome
Clinics
;
74: e509, 2019.
Article
in English
| LILACS
| ID: biblio-1011922
ABSTRACT
Acute respiratory distress syndrome (ARDS) is a life-threatening illness characterized by a complex pathophysiology, involving not only the respiratory system but also nonpulmonary distal organs. Although advances in the management of ARDS have led to a distinct improvement in ARDS-related mortality, ARDS is still a life-threatening respiratory condition with long-term consequences. A better understanding of the pathophysiology of this condition will allow us to create a personalized treatment strategy for improving clinical outcomes. In this article, we present a general overview p38 mitogen-activated protein kinase (p38MAPK) and recent advances in understanding its functions. We consider the potential of the pharmacological targeting of p38MAPK pathways to treat ARDS.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Respiratory Distress Syndrome, Newborn
/
Inflammation Mediators
/
P38 Mitogen-Activated Protein Kinases
Limits:
Humans
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2019
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Hubei University of Medicine/CN
Similar
MEDLINE
...
LILACS
LIS