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p38MAPK plays a pivotal role in the development of acute respiratory distress syndrome
Feng, Ying; Fang, Zhicheng; Liu, Boyi; Zheng, Xiang.
  • Feng, Ying; Hubei University of Medicine. Taihe Hospital. Department of Intensive Care Unit. Shiyan 442000. CN
  • Fang, Zhicheng; Hubei University of Medicine. Taihe Hospital. Department of Intensive Care Unit. Shiyan 442000. CN
  • Liu, Boyi; Hubei University of Medicine. Taihe Hospital. Department of Intensive Care Unit. Shiyan 442000. CN
  • Zheng, Xiang; Hubei University of Medicine. Taihe Hospital. Department of Intensive Care Unit. Shiyan 442000. CN
Clinics ; 74: e509, 2019.
Article in English | LILACS | ID: biblio-1011922
ABSTRACT
Acute respiratory distress syndrome (ARDS) is a life-threatening illness characterized by a complex pathophysiology, involving not only the respiratory system but also nonpulmonary distal organs. Although advances in the management of ARDS have led to a distinct improvement in ARDS-related mortality, ARDS is still a life-threatening respiratory condition with long-term consequences. A better understanding of the pathophysiology of this condition will allow us to create a personalized treatment strategy for improving clinical outcomes. In this article, we present a general overview p38 mitogen-activated protein kinase (p38MAPK) and recent advances in understanding its functions. We consider the potential of the pharmacological targeting of p38MAPK pathways to treat ARDS.
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Full text: Available Index: LILACS (Americas) Main subject: Respiratory Distress Syndrome, Newborn / Inflammation Mediators / P38 Mitogen-Activated Protein Kinases Limits: Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Hubei University of Medicine/CN

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Full text: Available Index: LILACS (Americas) Main subject: Respiratory Distress Syndrome, Newborn / Inflammation Mediators / P38 Mitogen-Activated Protein Kinases Limits: Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Hubei University of Medicine/CN