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Impairment induction by axotomy in motor functional and histological anterior horn of spinal cord structure / Inducción del deterioro por axotomía en la estructura motora funcional e histológica del asta anterior de la médula espinal
Raoofi, Amir; Gharibian, Saeed; Sadeghi, Yousef.
  • Raoofi, Amir; Sabzevar University of Medical Sciences. School of Medicine. Department of Anatomical Sciences. Sabzevar. IR
  • Gharibian, Saeed; Shahid Behesti University of Medical Sciences. Dental School. Research Institute of Dental Sciences. Tehran. IR
  • Sadeghi, Yousef; Shahid Beheshti University of Medical Sciences. School of Medicine. Department of Biology and Anatomical Sciences. Tehran. IR
Int. j. morphol ; 37(3): 1101-1106, Sept. 2019. tab, graf
Article in English | LILACS | ID: biblio-1012403
ABSTRACT
We have surveyed the motor changes in rats subjected to sciatic nerve axotomy. The rats were divided into two groups, each one consisting of ten animals, which underwent the following intervention The first group (control) healthy rats without any injuries and experimental group rats with injured sciatic nerve without treatment. at 12 weeks, the L4 and L5 spinal cord segments were removed. We evaluated nerve function using muscle electromyography (EMG) activity and sciatic function index (SFI) simultaneously with histological spinal cord analyses by stereological methods at 12 week. After nerve injury presented gross locomotor deficits at week 12. We also found that the volume of the anterior horn of spinal cord and total number of motor neurons were decreased after nerve axotomy (p<0.05). In conjunction, these results indicate that peripheral nerve injuries have more severe consequences on hind limb motor output.
RESUMEN
En este estudio se examinaron los cambios motores en ratas sometidas a axotomía del nervio ciático. Las ratas se dividieron en dos grupos diez animales. El primer grupo (control) eran ratas sanas sin lesiones, y el grupo experimental consistió en ratas con nervio ciático lesionado sin tratamiento. A las 12 semanas, los segmentos de la médula espinal L4 y L5 fueron removidos. Se evaluó la función nerviosa mediante electromiografía muscular (EMG) y el índice de función ciática (IFC), simultáneamente con análisis histológicos de la médula espinal mediante métodos estereológicos. A las 12 semanas de la lesión nerviosa presentó déficit locomotor grueso. Además, se observó que el volumen del asta anterior y el número total de neuronas motoras disminuyeron después de la axotomía nerviosa (P <0,05). En conjunto, estos resultados indican que las lesiones de los nervios periféricos determinan graves consecuencias de la función motora de los miembros posteriores.
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Full text: Available Index: LILACS (Americas) Main subject: Spinal Cord Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Sabzevar University of Medical Sciences/IR / Shahid Beheshti University of Medical Sciences/IR / Shahid Behesti University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Spinal Cord Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Sabzevar University of Medical Sciences/IR / Shahid Beheshti University of Medical Sciences/IR / Shahid Behesti University of Medical Sciences/IR