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The role of visfatin levels in gingival crevicular fluid as a potential biomarker in the relationship between obesity and periodontal disease
Çetiner, Deniz; Uraz, Ahu; Öztoprak, Seniha; Akça, Gülçin.
  • Çetiner, Deniz; Gazi University. Faculty of Dentistry. Department of Periodontology. Ankara. TR
  • Uraz, Ahu; Gazi University. Faculty of Dentistry. Department of Periodontology. Ankara. TR
  • Öztoprak, Seniha; Gazi University. Faculty of Dentistry. Department of Periodontology. Ankara. TR
  • Akça, Gülçin; Gazi University. Faculty of Dentistry. Department of Microbiology. Ankara. TR
J. appl. oral sci ; 27: e20180365, 2019. tab, graf
Article in English | LILACS, BBO | ID: biblio-1012506
ABSTRACT
Abstract Objectives Visfatin is an adipokine that plays an important role in immune functions as a growth factor, enzyme, and pro-inflammatory mediator. We aimed to determine the levels of visfatin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF) in both obese/non-obese patients, with/without generalized chronic periodontitis (GCP). Methodology Patients were categorized as obese (O) (n=31) or non-obese (nO) (n=19). Groups were divided into four subgroups according to periodontal conditions (1) periodontally healthy without obesity (nO-Ctrl); (2) GCP without obesity (nO-CP); (3) periodontally healthy with obesity (O-Ctrl); and (4) GCP with obesity (O-CP). Demographic variables, anthropometric and laboratory data were recorded. Periodontal parameters were measured at baseline and 3rd months after either non-surgical periodontal treatment or calorie -restricted diet therapy. At the same time, GCF samples were taken from patients to analyze TNF-alpha, IL-6,and visfatin levels. Results Periodontal parameters were significantly higher in the O group than in the nO group (P<0.05). IL-6 levels were higher in the O group than in the nO group (P<0.001). The visfatin levels of the obese patients were reduceddecreased following the treatments (P<0.05). Cholesterol levels were higher in the O group than in the nO groups (P<0.05). IL-6 levels were higher in O-CP and O-Ctrl groups than in the nO-Ctrl group (P<0.05). Compared to the other groups, visfatin levels were significantly higher in the O-CP group but decreased following treatment (P<0.05). Conclusions Our findings suggest that visfatin and IL-6 levels in GCF are associated with the pathogenesis of obesity and periodontitis. Within the limits of this study, we considered that there might be an association between the lipid profile and periodontitis on systemically healthy individuals.
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Full text: Available Index: LILACS (Americas) Main subject: Periodontitis / Cytokines / Gingival Crevicular Fluid / Interleukin-6 / Tumor Necrosis Factor-alpha / Nicotinamide Phosphoribosyltransferase / Obesity Type of study: Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2019 Type: Article Affiliation country: Turkey Institution/Affiliation country: Gazi University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Periodontitis / Cytokines / Gingival Crevicular Fluid / Interleukin-6 / Tumor Necrosis Factor-alpha / Nicotinamide Phosphoribosyltransferase / Obesity Type of study: Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2019 Type: Article Affiliation country: Turkey Institution/Affiliation country: Gazi University/TR