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Initial inflammatory response after the pulpotomy of rat molars with MTA or ferric sulfate
Lopes, Camila Soares; Junqueira, Marina Azevedo; Cosme-Silva, Leopoldo; Pegoraro, Camila de Oliveira Rodini; Garbelini, Cássia Cilene Dezan; Oliveira, Thais Marchini; Martins, Natália Silva; Neves, Juliana dos Santos; Sakai, Vivien Thiemy.
  • Lopes, Camila Soares; Universidade Federal de Alfenas. Faculdade de Odontologia. Departamento de Clínica e Cirurgia. Alfenas. BR
  • Junqueira, Marina Azevedo; Universidade Federal de Alfenas. Faculdade de Odontologia. Departamento de Clínica e Cirurgia. Alfenas. BR
  • Cosme-Silva, Leopoldo; Universidade do Estado de São Paulo. Faculdade de Odontologia de Araçatuba. Departamento de Endodontia. Araçatuba. BR
  • Pegoraro, Camila de Oliveira Rodini; Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas. Bauru. BR
  • Garbelini, Cássia Cilene Dezan; Universidade Estadual de Londrina. Departamento de Medicina Bucal e Odontopediatria. Londrina. BR
  • Oliveira, Thais Marchini; Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Odontopediatria, Ortodontia e Saúde Coletiva. Bauru. BR
  • Martins, Natália Silva; Universidade Federal de Alfenas. Instituto de Exatas. Departamento de Estatística. Alfenas. BR
  • Neves, Juliana dos Santos; Universidade Federal de Alfenas. Departamento de Biologia Estrutural. Alfenas. BR
  • Sakai, Vivien Thiemy; Universidade Federal de Alfenas. Faculdade de Odontologia. Departamento de Clínica e Cirurgia. Alfenas. BR
J. appl. oral sci ; 27: e20180550, 2019. tab, graf
Article in English | LILACS, BBO | ID: biblio-1012512
ABSTRACT
Abstract Purpose To compare, both qualitatively and quantitatively, the inflammatory cells, vascular density and IL-6 immunolabeled cells present in the pulp after pulpotomy with white MTA versus 15.5% ferric sulfate (FS). Methodology Forty-eight mandibular first molars from 24 Wistar rats were divided into MTA or FS groups and subdivided according to the period after pulpotomy procedure (24, 48 and 72 hours). Four teeth (sound and untreated) were used as controls. Histological sections were obtained and assessed through the descriptive analysis of morphological aspects of pulp tissue and the quantification of inflammatory cells, vascular density and interleukin-6 (IL-6) expression. Data were statistically analyzed (p<0.05). Results The number of inflammatory cells was similar in both groups, being predominantly localized at the cervical radicular third. In the MTA group, increased inflammation was observed at 48 hours. Vascular density was similar in both groups and over time, being predominant in the medium radicular third. No correlation was found between the number of inflammatory cells and the vascular density. Pulp tissue was more organized in MTA-treated teeth. In both groups, a weak to moderate IL-6 expression was detected in odontoblasts and inflammatory cells. Comparing both groups, there was a greater IL-6 expression in the cervical radicular third of teeth treated with MTA at 24 hours and in the medium and apical thirds at 72 hours, while in the FS group a greater IL-6 expression was found in the apical third at 24 hours. Conclusion The MTA group presented better histological features and greater IL-6 expression than the FS group. However, no difference was observed between the groups regarding the inflammatory status and vascularization, suggesting the usefulness of FS as a low-cost alternative to MTA.
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Full text: Available Index: LILACS (Americas) Main subject: Oxides / Pulpotomy / Ferric Compounds / Interleukin-6 / Silicates / Calcium Compounds / Aluminum Compounds / Inflammation Limits: Animals Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Londrina/BR / Universidade Federal de Alfenas/BR / Universidade de São Paulo/BR / Universidade do Estado de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Oxides / Pulpotomy / Ferric Compounds / Interleukin-6 / Silicates / Calcium Compounds / Aluminum Compounds / Inflammation Limits: Animals Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Londrina/BR / Universidade Federal de Alfenas/BR / Universidade de São Paulo/BR / Universidade do Estado de São Paulo/BR