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Association of fecal occult blood tests results with colonoscopic findings in a general hospital and validation of the screening test / Achados colonoscópicos em pacientes submetidos a exame de sangue oculto nas fezes e validacão deste teste de triagem
Saraceni, Ana Flávia; Azevedo, Rodrigo; Almeida, Clarissa Maria Gomes; Baraviera, Antônio Carlos; Kiss, Desiderio Roberto; Almeida, Maristela Gomes.
  • Saraceni, Ana Flávia; Complexo Hospitalar Professor Edmundo Vasconcelos. São Paulo. BR
  • Azevedo, Rodrigo; Complexo Hospitalar Professor Edmundo Vasconcelos. São Paulo. BR
  • Almeida, Clarissa Maria Gomes; Faculdade de Medicina do ABC (FMABC). Santo André. BR
  • Baraviera, Antônio Carlos; Complexo Hospitalar Professor Edmundo Vasconcelos. São Paulo. BR
  • Kiss, Desiderio Roberto; Complexo Hospitalar Professor Edmundo Vasconcelos. São Paulo. BR
  • Almeida, Maristela Gomes; Complexo Hospitalar Professor Edmundo Vasconcelos. São Paulo. BR
J. coloproctol. (Rio J., Impr.) ; 39(2): 121-126, Apr.-June 2019. tab, ilus
Article in English | LILACS | ID: biblio-1012590
ABSTRACT
ABSTRACT Globally, colorectal cancer is the third leading cause of cancer death among men and the second among women, corresponding to about 10% of all cancers. The Brazilian Ministry of Health and National Cancer Institute recommend the screening of colorectal cancer for people over 50 years-old with Fecal Occult Blood Test. Endoscopy is limited to patients with positive screening results. The aim of this study is to evaluate the incidence of malignant or premalignant lesions diagnosed by endoscopy in patients with positive or negative Fecal Occult Blood Test and assess the efficacy of Fecal Occult Blood Test to predict the finding of a malignant colorectal lesion. We carried out a cross-sectional study among patients with a Fecal Occult Blood Test result that were submitted to colonoscopy, in the same hospital, from March 2016 to July 2017. Sensitivity, specificity, positive and negative predictive value of Fecal Occult Blood Test compared to colonoscopy neoplastic findings was calculated. The total of 92 patients were enrolled, 52 (56.5%) were female, Fecal Occult Blood Test was positive in 42.4% of them and in 41 (44.6%) the colonoscopy showed abnormal findings. Polyps were the most frequent alteration, found in 20 patients (21.7%). Among the patients with polyps, 15 (16.3%) had neoplastic and 5 (5.4%) presented non-neoplastic polyps. The Fecal Occult Blood Test sensitivity for detection of neoplastic polyps was 66.7%, specificity 62.3%, positive predictive value 11% and negative predictive value was 94.2%. Considering the need for a screening method, Fecal Occult Blood Test showed to be an effective and reliable screening test that can be applied in public health programs to detect and prevent colorectal cancer.
RESUMO
RESUMO Globalmente, o carcinoma colorretal é a terceira principal causa de morte por neoplasia entre homens e a segunda entre mulheres, correspondendo a 10% de todas as neoplasias. O Ministério da Saúde Brasileiro e o Instituto Nacional do Câncer recomendam a triagem do câncer colorretal para indivíduos acima de 50 anos, utilizando a Pesquisa de Sangue Oculto nas fezes. A endoscopia é reservada para aqueles com Pesquisa de Sangue Oculto nas fezes positiva. O objetivo deste estudo é avaliar a incidência de lesões malignas/pré-malignas diagnósticas na colonoscopia e correlacionar com os resultados prévios da Pesquisa de Sangue Oculto e verificar a eficácia da Pesquisa de Sangue Oculto para predizer uma lesão colorretal maligna. Realizamos um estudo transversal em pacientes que apresentavam resultados positivos ou negativos de Pesquisa de Sangue Oculto nas fezes e foram submetidos à colonoscopia, na mesma instituição, entre março de 2016 e julho de 2017. Dos 92 participantes; 52 (56,5%) eram do sexo feminino, a Pesquisa de Sangue Oculto nas fezes foi positiva em 42,4%; e em 41 (44,6%) a colonoscopia mostrou alterações. Em 20 pacientes (21,7%) havia pólipos; 15 (16,3%) eram neoplásicos e 5 (5,4%) não neoplásicos. A sensibilidade da Pesquisa de Sangue Oculto nas fezes para detecção de pólipos neoplásicos foi 66,7%; a especificidade 62,3%; o valor preditivo positivo 11% e o valor preditivo negativo 94,2%. Considerando a necessidade de um método de triagem, a Pesquisa de Sangue Oculto nas fezes mostrou ser um exame de triagem eficaz e confiável para ser aplicado em programas de saúde pública com o objetivo de detectar e prevenir o carcinoma colorretal.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Colorectal Neoplasms / Colonic Diseases / Occult Blood Type of study: Diagnostic study / Observational study / Prevalence study / Prognostic study / Risk factors / Screening study Limits: Female / Humans / Male Language: English Journal: J. coloproctol. (Rio J., Impr.) Journal subject: Cirurgia / Doen‡as Retais / Doen‡as do Colo / Gastroenterology / Cirurgia Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Complexo Hospitalar Professor Edmundo Vasconcelos/BR / Faculdade de Medicina do ABC (FMABC)/BR

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Full text: Available Index: LILACS (Americas) Main subject: Colorectal Neoplasms / Colonic Diseases / Occult Blood Type of study: Diagnostic study / Observational study / Prevalence study / Prognostic study / Risk factors / Screening study Limits: Female / Humans / Male Language: English Journal: J. coloproctol. (Rio J., Impr.) Journal subject: Cirurgia / Doen‡as Retais / Doen‡as do Colo / Gastroenterology / Cirurgia Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Complexo Hospitalar Professor Edmundo Vasconcelos/BR / Faculdade de Medicina do ABC (FMABC)/BR