Your browser doesn't support javascript.
loading
Pretreatment of hepatetctomized rats with Coleus forskohlii did not interfere with the course of hepatic hyperplasia
Barros, Pedro Paulo; Gonçalves, Gisele Mara Silva; Silva, Gustavo Henrique da; Fava, Ana Laura Masquetti.
  • Barros, Pedro Paulo; Pontifícia Universidade Católica de Campinas. Faculty of Pharmaceutical Sciences. Campinas. BR
  • Gonçalves, Gisele Mara Silva; Pontifícia Universidade Católica de Campinas. Faculty of Pharmaceutical Sciences. Campinas. BR
  • Silva, Gustavo Henrique da; Pontifícia Universidade Católica de Campinas. Faculty of Pharmaceutical Sciences. Campinas. BR
  • Fava, Ana Laura Masquetti; PUC. Faculty of Pharmaceutical Sciences. Campinas. BR
Acta cir. bras ; 34(6): e201900607, 2019. tab, graf
Article in English | LILACS | ID: biblio-1019264
Responsible library: BR1.1
ABSTRACT
Abstract Purpose Coleus forskohlii Briq., a medicinal plant originally from India, has been indicated against heart disease, expiratory disorders, convulsions, and hepatic changes, among others. In view of the broad pharmacological potential of the plant and the scarce information about its effects, the objective of the present study was to investigate the effect of its use for pretreatment of partially hepatectomized rats. Methods The animals were divided into two experimental groups Control (CG) receiving physiological saline for 10 days before partial hepatetctomy, and Treated (TG) receiving 40 mg Coleus forskohlii/kg/day for 10 days before partial hepatectomy. The treatments were performed by gastric gavage. After the surgical procedure, treatment was continued according to the following groups CG 24 h, CG 48 h, TG 24 h, and TG 48 hs, and liver tissue and intracardiac blood samples were obtained for histological and biochemical analysis, respectively. Results No significant differences were observed in mitotic or apoptotic index or in the concentrations of the enzymes AST, ALT and alkaline phosphatase, and no areas of fibrosis were detected. Conclusion Treatment with Coleus forskohlii did not interfere with the course of hepatic hyperplasia.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Plectranthus / Hepatectomy / Liver Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: PUC/BR / Pontifícia Universidade Católica de Campinas/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Plectranthus / Hepatectomy / Liver Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: PUC/BR / Pontifícia Universidade Católica de Campinas/BR