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Glycogen synthase kinase-3 beta inhibitors protectagainst the acute lung injuries resulting from acute necrotizing pancreatitis
Jin, Hongzhong; Yang, Xiaojia; Zhao, Kailiang; Zhao, Liang; Chen, Chen; Yu, Jia.
  • Jin, Hongzhong; Wuhan University. Renmin Hospital. Department of Hepatobiliary Surgery. Hubei Province. CN
  • Yang, Xiaojia; Wuhan University. Renmin Hospital. Department of Hepatobiliary Surgery. Hubei Province. CN
  • Zhao, Kailiang; Wuhan University. Renmin Hospital. Department of Hepatobiliary Surgery. Hubei Province. CN
  • Zhao, Liang; Wuhan University. Renmin Hospital. Department of Hepatobiliary Surgery. Hubei Province. CN
  • Chen, Chen; Wuhan University. Renmin Hospital. Department of Hepatobiliary Surgery. Hubei Province. CN
  • Yu, Jia; Wuhan University. Renmin Hospital. Department of Hepatobiliary Surgery. Hubei Province. CN
Acta cir. bras ; 34(6): e201900609, 2019. tab, graf
Article in English | LILACS | ID: biblio-1019266
ABSTRACT
Abstract Purpose The research is intended for clarification of the efficacy as well as the underlying mechanism of GSK-3β inhibitors on the advancement of acute lung injuries in acute necrotizing pancreatitis (ANP) in rats. Methods Seventy-two rats were randomly divided into 6 groups (1)ANP-vehicle; (2)ANP-TDZD-8;(3)ANP-SB216763;(4)Sham-vehicle;(5)Sham-TDZD-8;(6)Sham-SB216763; Blood biochemical test, histopathological examination and immunohistochemical analysis of rats pancreas and lung tissues were performed. The protein expression of GSK-3β, phospho-GSK-3β (Ser9), iNOS, ICAM-1, TNF-α, and IL-10 were detected in lung tissues by Western-blot. Results The outcomes revealed that the intervention of GSK-3β inhibitors alleviated the pathological damage of pancreas and lung (P<0.01), reduced serum amylase, lipase, hydrothorax and lung Wet-to-Dry Ratio, attenuated serum concentrations of IL-1β and IL-6 (P<0.01), inhibited the activation of NF-κB, and abated expression of iNOS, ICAM-1 and TNF-α protein, but up-regulated IL-10 expression in lung of ANP rats (P<0.01). The inflammatory response and various indicators in ANP-TDZD-8 groups were lower than those in ANP-SB216763 groups. Conclusions Inhibition of GSK-3β weakens acute lung injury related to ANP via the inhibitory function of NF-κB signaling pathway. Different kinds of GSK-3β inhibitors have different effects to ANP acute lung injury.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pancreatitis, Acute Necrotizing / Acute Lung Injury / Glycogen Synthase Kinase 3 beta Type of study: Etiology study / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Wuhan University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Pancreatitis, Acute Necrotizing / Acute Lung Injury / Glycogen Synthase Kinase 3 beta Type of study: Etiology study / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Wuhan University/CN