Your browser doesn't support javascript.
loading
Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population
Lelis, Deborah de Farias; Pereira, Alexandre Costa; Krieger, José Eduardo; Mill, José Geraldo; Santos, Sérgio Henrique Sousa; Baldo, Marcelo Perim.
  • Lelis, Deborah de Farias; Universidade Estadual de Montes Claros. Programa de Pós-Graduação em Ciências da Saúde. Montes Claros. BR
  • Pereira, Alexandre Costa; Universidade de São Paulo. Instituto do Coração. São Paulo. BR
  • Krieger, José Eduardo; Universidade de São Paulo. Instituto do Coração. São Paulo. BR
  • Mill, José Geraldo; Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória. BR
  • Santos, Sérgio Henrique Sousa; Universidade Estadual de Montes Claros. Programa de Pós-Graduação em Ciências da Saúde. Montes Claros. BR
  • Baldo, Marcelo Perim; Universidade Estadual de Montes Claros. Programa de Pós-Graduação em Ciências da Saúde. Montes Claros. BR
Arch. endocrinol. metab. (Online) ; 63(4): 402-410, July-Aug. 2019. tab, graf
Article in English | LILACS | ID: biblio-1019361
ABSTRACT
ABSTRACT Objective The increased prevalence of obesity and associated comorbidities, such as cardiovascular and metabolic diseases, has gained attention worldwide, and the renin-angiotensin system (RAS) has been pointed out as a possible link. Thus, the present study aimed to verify the possible association between angiotensinogen (AGT) or angiotensin-converting enzyme (ACE) polymorphisms with overweight and obesity in adults. Subjects and methods The present investigation was a population-based cross-sectional study including 1,567 individuals from an urban area in Brazil. Anthropometric, clinical and biochemical parameters were evaluated, and all individuals were genotyped for the ACE I/D and AGT M/T polymorphisms. Results The prevalence of overweight was higher among men, whereas obesity was more prevalent among women. However, the frequency of ACE or AGT polymorphisms was similar among body mass index (BMI) categories. In addition, the mean age-adjusted BMI averages did not change significantly for ACE or AGT polymorphisms, regardless of sex or BMI category. The age-adjusted BMI average for the combination of ACE and AGT genotypes evidenced no significant differences regardless of sex or BMI categories. Results were similar when BMI was replaced by waist circumference (WC). Conclusions We were not able to find any associations between BMI and WC (overweight/obesity) and ACE and AGT polymorphisms, indicating that the RAS system might not be involved in overweight and obesity, at least based on genetic backgrounds. However, further studies must measure RAS components to elucidate this question.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Renin-Angiotensin System / Overweight / Obesity Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Montes Claros/BR / Universidade Federal do Espírito Santo/BR / Universidade de São Paulo/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Renin-Angiotensin System / Overweight / Obesity Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Montes Claros/BR / Universidade Federal do Espírito Santo/BR / Universidade de São Paulo/BR