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Metabolic phenotypes of obese, overweight, and normal weight individuals and risk of chronic kidney disease: a systematic review and meta-analysis
Alizadeh, Shahab; Esmaeili, Hamed; Alizadeh, Mohammad; Daneshzad, Elnaz; Sharifi, Loghman; Radfar, Hossein; Radaei, Mohammad Kazem.
  • Alizadeh, Shahab; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Clinical Nutrition. Tehran. IR
  • Esmaeili, Hamed; Baqiyatallah University of Medical Sciences. Faculty of Health. Department of Nutrition and Food Hygiene. Tehran. IR
  • Alizadeh, Mohammad; Mazandaran University of Medical Sciences. Nasibeh Nursing & Midwifery School. Department of Medical Surgical Nursing. Sari. IR
  • Daneshzad, Elnaz; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Community Nutrition. Tehran. IR
  • Sharifi, Loghman; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Radfar, Hossein; Kharazmi University. hysical Education and Sport Science College. Department of Sports Biomechanics. Tehran. IR
  • Radaei, Mohammad Kazem; Baqiyatallah University of Medical Sciences. Faculty of Health. Department of Nutrition and Food Hygiene. Tehran. IR
Arch. endocrinol. metab. (Online) ; 63(4): 427-437, July-Aug. 2019. tab, graf
Article in English | LILACS | ID: biblio-1019362
ABSTRACT
ABSTRACT Objective Chronic kidney disease (CKD) risk is inconsistent in the normal-weight, overweight, and obese individuals due to the heterogeneity of metabolic status. This meta-analysis aimed to examine the combined effects of body mass index (BMI) and metabolic status on CKD risk. Materials and methods The MEDLINE, EMBASE, and Web of Knowledge databases were systematically searched up to March 2019 to identify all eligible studies investigating the CKD risk (defined as GFR < 60 mL/min per 1.73 m2 and/or microalbuminuria or proteinuria) associated with the body size phenotypes which are known as metabolically unhealthy normal-weight (MUNW), metabolically healthy overweight (MHOW), metabolically unhealthy overweight, metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO). The classification of subjects in included studies as metabolically unhealthy was based on the presence of three components of metabolic syndrome. BMI categorization was based on the criteria of included studies. The risk estimates and 95% confidence intervals (CIs) were extracted and pooled using random effects analysis. Results A total of 9 prospective cohort studies with 128773 participants and 4797 incident cases were included in the meta-analysis. Compared with healthy normal-weight individuals as reference, MUNW and MHO subjects showed an increased risk for CKD events with a pooled RR of 1.58 (95% CI = 1.28-1.96) in MUNW and 1.55 (95% CI = 1.34-1.79) in MHO persons. Also, MHOW was at increased risk for CKD (RR = 1.34, 95% CI = 1.20-1.51). MUHO individuals were at the highest risk for the development of CKD (RR = 2.13, 95% CI = 1.66-2.72). Conclusions Individuals with metabolic abnormality, although at normal-weight, have an increased risk for CKD. Healthy overweight and obese individuals had higher risk; refuting the notion that metabolically healthy overweight and obese phenotypes are benign conditions.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Phenotype / Body Weight / Metabolic Syndrome / Renal Insufficiency, Chronic Type of study: Etiology study / Observational study / Prognostic study / Risk factors / Systematic reviews Limits: Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Baqiyatallah University of Medical Sciences/IR / Kharazmi University/IR / Mazandaran University of Medical Sciences/IR / Tehran University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Phenotype / Body Weight / Metabolic Syndrome / Renal Insufficiency, Chronic Type of study: Etiology study / Observational study / Prognostic study / Risk factors / Systematic reviews Limits: Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Baqiyatallah University of Medical Sciences/IR / Kharazmi University/IR / Mazandaran University of Medical Sciences/IR / Tehran University of Medical Sciences/IR