TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells
Biol. Res
;
52: 35, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1019500
ABSTRACT
BACKGROUND:
Non-small cell lung cancer (NSCLC) is one of the leading causes of death in the world. NSCLC diagnosed at an early stage can be highly curable with a positive prognosis, but biomarker limitations make it difficult to diagnose lung cancer at an early stage. To identify biomarkers for lung cancer development, we previously focused on the oncogenic roles of transcription factor TFAP2C in lung cancers and revealed the molecular mechanism of several oncogenes in lung tumorigenesis based on TFAP2C-related microarray analysis.RESULTS:
In this study, we analyzed microarray data to identify tumor suppressor genes and nine genes downregulated by TFAP2C were screened. Among the nine genes, we focused on growth arrest and DNA-damage-inducible beta (GADD45B) and phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) as representative TFAP2C-regulated tumor suppressor genes. It was observed that overexpressed TFAP2C resulted in inhibition of GADD45B and PMAIP1 expressions at both the mRNA and protein levels in NSCLC cells. In addition, downregulation of GADD45B and PMAIP1 by TFAP2C promoted cell proliferation and cell motility, which are closely associated with NSCLC tumorigenesis.CONCLUSION:
This study indicates that GADD45B and PMAIP1 could be promising tumor suppressors for NSCLC and might be useful as prognostic markers for use in NSCLC therapy.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Antigens, Differentiation
/
Down-Regulation
/
Carcinoma, Non-Small-Cell Lung
/
Cell Proliferation
/
Transcription Factor AP-2
/
Lung Neoplasms
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2019
Type:
Article
Affiliation country:
South Korea
Institution/Affiliation country:
Korea National University of Education/KR
/
Pusan National University/KR
/
Sejong University/KR
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