The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels
Braz. oral res. (Online)
;
33: e055, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1019595
ABSTRACT
Abstract Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30-65 years) without other diseases, except for chronic periodontitis (CP). Patients were allocated to either CP or control groups. The CP group received supragingival and subgingival scaling and root planing procedures, whereas the control group received supragingival scaling. Probing depth (PD), bleeding on probing, clinical attachment level (CAL), visible plaque index (VPI), serum hepcidin and interleukin-6 (IL-6) levels, high-sensitivity C-reactive protein (hs-CRP), hematological markers, and iron markers were measured at baseline and at 90 days after NSPT. The CP group had statistically significant lower mean values for mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (p ≤ 0.05). The control group had statistically significant reductions in hemoglobin, hematocrit, MCV, and MCH (p ≤ 0.05). Serum hepcidin, IL-6, and erythrocyte sedimentation rate (ESR) levels were significantly decreased in both groups after NSPT. Periodontal markers were more markedly reduced in the CP group compared with the control group (p ≤ 0.05). These findings suggest that NSPT may reduce the serum levels of IL-6, hepcidin, and periodontal parameters.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Chronic Periodontitis
/
Hepcidins
/
Iron
Type of study:
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. oral res. (Online)
Journal subject:
Dentistry
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital Universitário da Universidade Federal do Maranhão/BR
/
Universidade Estadual de Feira de Santana - UEFS/BR
/
Universidade Federal de Juiz de Fora - UFJF/BR
/
Universidade Federal do Maranhão - UFMA/BR
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