Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis
Braz. oral res. (Online)
;
33: e077, 2019. tab
Article
in English
| LILACS
| ID: biblio-1019597
ABSTRACT
Abstract The aim of the present study was to identify the relationship between the expression of calcitonin gene-related peptide (CGRP) and the responses of pulp sensitivity tests in healthy pulps and irreversible pulps by performing a cross-sectional study on patients. Two hundred subjects were evaluated. A total of 75 subjects complied with the criteria. The participants were divided into two groups a) Healthy pulp (subjects [n = 35] having posterior teeth with clinically normal pulp tissue), and b) Irreversible pulpitis (subjects [n = 40] having posterior teeth with irreversible pulpitis). All participants were evaluated using the following variables a) medical and dental history, b) pulp sensitivity tests, c) expression of CGRP by the enzyme-linked immunosorbent assay (ELISA), and d) expression levels of mRNA CGRP and mRNA CGRP receptor genes. We determined that the responses of the cold test between 4 and ≥12 s presented a higher average of the expression of CGRP in the group having irreversible pulpitis (p = 0.0001). When we compared the groups with the value of the electrical impulse, we found statistically significant differences (p = 0.0001), observing positive responses to the test with electrical impulses of 7 to 10, with an average of 72.15 ng/mL of CGRP in the irreversible pulpitis group. High values of CGRP expression were observed in that group in the responses of pulp sensitivity.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pulpitis
/
Calcitonin Gene-Related Peptide
/
Dental Pulp
/
Dental Pulp Test
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. oral res. (Online)
Journal subject:
Dentistry
Year:
2019
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Autonomous University of The State of Hidalgo/MX
/
University of San Luis Potosí/MX
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