Correlation of Beta-2 Adrenergic Receptor Expression inTumor-Free Surgical Margin and at the Invasive Front ofOral Squamous Cell Carcinoma
Journal of Oncology
;
3531274: 1-8, 2016.
Article
in English
| SES-SP, LILACS
| ID: biblio-1024473
ABSTRACT
Background. The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis. Objectives. The present study aimed to analyze the expression of the beta-2 adrenergic receptor (ß2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front. Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study. The clinicopathological data and clinical follow-up were obtained from medical records and their association with ß2-AR expression was verified by the chi-square test or Fischer's exact test. To verify the correlation of ß2-AR expression in tumor-free surgical margins and at the invasive front of OSCCs, Pearson's correlation coefficient test was applied. Results. The expression of ß2-AR presented a statistically significant correlation between the tumor-free surgical margins and the invasive front of OSCC (r = 0.383; p = 0.002). The immunohistochemical distribution of ß2-AR at the invasive front of OSCC was also statistically significant associated with alcohol (p = 0.038), simultaneous alcohol and tobacco consumption (p = 0.010), and T stage (p = 0.014). Conclusions. The correlation of ß2-AR expression in OSCC and tumor-free surgical margins suggests a role of this receptor in tumor progression and its expression in normal oral epithelium seems to be constitutive
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Carcinoma
/
Carcinoma, Squamous Cell
/
Adrenergic Agents
Language:
English
Journal:
Journal of Oncology
Year:
2016
Type:
Article
Institution/Affiliation country:
A.C. Camargo Cancer Center,/BR
/
Secretaria da Saúde do Estado de São Paulo/BR
/
Universidade Estadual Paulista/BR
/
Universidade de São Paulo/BR
/
University Hospital and School of Medicine of Santiago de Compostela/ES
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