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Myosin 1H and the soft tissue profile of african american females with mandibular prognathism
Burnheimer, John; Deeley, Kathleen; Vieira, Alexandre R.
  • Burnheimer, John; Universidade de Pittsburgh. Departamento de Ortodontia e Ortopedia Dentofacial. US
  • Deeley, Kathleen; Universidade de Pittsburgh. Departamento de Biologia Oral. US
  • Vieira, Alexandre R; Universidade de Pittsburgh. Departamento de Biologia Oral. US
Rev. Cient. CRO-RJ (Online) ; 4(2): 35-41, May-Aug. 2019.
Article in English | LILACS, BBO | ID: biblio-1024848
ABSTRACT

Introduction:

The aim of this study was to explore the influence of Myosin 1H on the soft tissue profile of African American females.

Methods:

Fourteen African American females from the University of Pittsburgh School of Dental Medicine Dental Registry and DNA Repository with the ancestral genotype GG, marker rs10850110, locus 12q24.11 were analyzed. For this investigation, measurements were taken of the eleven items that comprise the Holdaway soft tissue analysis. Profile differences between ethnicity and corresponding normative values were explored by independent-sample t tests for all facial profile measurements. Student's t test for independent means was used to determine differences with accepted norms. Significance was set a p<0.05.

Results:

There were significant differences between four of the eleven Holdaway values and the reported values for African Americans. The mean convexity value of the African American female group was 1.0 mm less the normative value of 5.7 mm (p>0.000). In contrast, the H angle of the African American females was larger than the normative value.

Conclusions:

Our study confirms previous research that Myosin 1H contributes to mandibular prognathism. It agrees with the idea that Myosin 1H is less influential in the maxillary soft tissue complex. Understanding the genetic influence of soft tissue growth would allow improved therapies and prevention approaches.
RESUMO

Introduçâo:

O objetivo desse estudo foi determinar a influência da miosina 1H nos tecidos moles de mulheres americanas negras.

Métodos:

Foram estudadas quatorze mulheres americanas negras participantes do projeto Dental Registry and DNA Repository da Faculdade de Odontologia da Universidade de Pittsburgh com o genótipo comum GG do marcador rs10850110, localizado no lócus 12q24.11. Medidas de onze parâmetros que compõem a análise de tecidos moles de Holdaway foram utilizadas. Diferenças entre etnicidade e medidas normais correspondentes, foram exploradas através do teste t de Student de amostras independentes para todas as medidas faciais. O teste t de Student para médias independentes foi usado para determinar diferenças em comparação à medidas normais. A significância foi estabelecida em p<0,05.

Resultados:

Houve uma diferença estatisticamente significante entre quatro das onze medidas de Holdaway. A convexidade média da mulher americana negra foi de 1,0 mm a menos que o valor normal de 5.7 mm (p>0.000). Em contraste, o ângulo H das mulheres americanas negras foi maior que o valor normal.

Conclusões:

O nosso estudo confirma resultados anteriores que a miosina 1H contribui para o prognatismo mandibular. Nossos resultados concordam com a ideia de que a miosina 1H tem menor influência nos tecidos moles da maxila. Entender a influência genética no crescimento dos tecidos moles irá possivelmente permitir melhorar as abordagens de tratamento e prevenção atuais.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Jaw Abnormalities Language: English Journal: Rev. Cient. CRO-RJ (Online) Journal subject: Medicina Cl¡nica / Odontologia / Patologia Year: 2019 Type: Article Affiliation country: United States Institution/Affiliation country: Universidade de Pittsburgh/US

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Full text: Available Index: LILACS (Americas) Main subject: Jaw Abnormalities Language: English Journal: Rev. Cient. CRO-RJ (Online) Journal subject: Medicina Cl¡nica / Odontologia / Patologia Year: 2019 Type: Article Affiliation country: United States Institution/Affiliation country: Universidade de Pittsburgh/US