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Etanercept in erythema nodosum leprosum
Santos, Julia Rocha Silva; Vendramini, Dâmia Leal; Nery, José Augusto da Costa; Avelleira, João Carlos Regazzi.
  • Santos, Julia Rocha Silva; Santa Casa de Misericórdia do Rio de Janeiro. Professor Rubem David Azulay Dermatology Institute. Rio de Janeiro. BR
  • Vendramini, Dâmia Leal; Santa Casa de Misericórdia do Rio de Janeiro. Professor Rubem David Azulay Dermatology Institute. Rio de Janeiro. BR
  • Nery, José Augusto da Costa; Santa Casa de Misericórdia do Rio de Janeiro. Professor Rubem David Azulay Dermatology Institute. Rio de Janeiro. BR
  • Avelleira, João Carlos Regazzi; Santa Casa de Misericórdia do Rio de Janeiro. Professor Rubem David Azulay Dermatology Institute. Rio de Janeiro. BR
An. bras. dermatol ; 92(4): 575-577, July-Aug. 2017. graf
Article in English | LILACS | ID: biblio-1038255
ABSTRACT
Abstract One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the use of thalidomide and/or prednisone for long periods of time, in turn increasing the risk of side effects. Two reports of the use of antiTNF to treat erythema nodosum leprosum were found in the literature. A good response was found after an assay with infliximab and etanercept. This study reports on a patient with lepromatous leprosy and recurrent reaction, controlled by using etanercept and a 10-month follow-up, with the interruption of thalidomide and the maintenance of prednisone at 10 mg/day.
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Full text: Available Index: LILACS (Americas) Main subject: Leprosy, Lepromatous / Anti-Inflammatory Agents, Non-Steroidal / Erythema Nodosum / Etanercept Limits: Adult / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Santa Casa de Misericórdia do Rio de Janeiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: Leprosy, Lepromatous / Anti-Inflammatory Agents, Non-Steroidal / Erythema Nodosum / Etanercept Limits: Adult / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Santa Casa de Misericórdia do Rio de Janeiro/BR