Vitiligo patients show significant up-regulation of aryl hydrocarbon receptor transcription factor
An. bras. dermatol
;
93(2): 302-303, Mar.-Apr. 2018. graf
Article
in English
| LILACS
| ID: biblio-1038265
ABSTRACT
Abstract IL-22 has been implicated in the pathogenesis of vitiligo. However, the role of aryl hydrocarbon receptor transcription factor that acts as a master regulator of IL-22-producing Th22 cells is not fully understood. The goal of this study was to investigate the expression pattern of aryl hydrocarbon receptor in peripheral blood mononuclear cells of patients with vitiligo and in normal controls. Transcript levels were determined by a reverse transcription quantitative real-time polymerase chain reaction. Aryl hydrocarbon receptor mRNA expression was drastically increased in patients with vitiligo compared to healthy controls (P = 0.000). Th22 cells may contribute to abnormal immune responses underlying vitiligo.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Vitiligo
/
Up-Regulation
/
Receptors, Aryl Hydrocarbon
/
Basic Helix-Loop-Helix Transcription Factors
Type of study:
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2018
Type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
National Institute of Genetic Engineering and Biotechnology Tehran/IR
/
Tehran University of Medical Sciences/IR
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