No detection of c-kit gene mutations in exons 9, 11, 13 and 17 and low CD117 expression in plaque-stage mycosis fungoides
An. bras. dermatol
;
93(6): 913-915, Nov.-Dec. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-1038285
ABSTRACT
Abstract The growth factor receptor c-kit (CD117) is expressed in immature T-cells and in some advanced forms of mycosis fungoides. c-kit gene mutation results in unrestricted neoplastic proliferation. We aimed to detect by PCR the most frequent exon mutations in seventeen plaque-stage MF patients, in their perilesional skin and in healthy skin donors. We secondarily evaluated CD117 expression by immunohistochemistry in plaque-stage and tumor-stage MF. We detected no mutation in c-kit gene and low CD117 expression was confirmed on atypical cells in one patient. Complete c-kit exon and intron sequences should be assessed and more sensitive sequencing method could be also applied.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Exons
/
Mycosis Fungoides
/
Proto-Oncogene Proteins c-kit
/
Mutation
Type of study:
Diagnostic study
/
Observational study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2018
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Hospital Italiano de Buenos Aires/AR
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