Serum amyloid A levels in acute and chronic urticaria
An. bras. dermatol
;
94(4): 411-415, July-Aug. 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1038290
ABSTRACT
Abstract Background:
Serum amyloid A is an acute-phase protein. There is no available data regarding serum amyloid A levels in patients with acute and chronic urticaria (CU).Objective:
To investigate the association between serum amyloid A and urticaria.Methods:
This was a case-control study of 81 patients who visited our Hospital between June and December 2016 with a diagnosis of urticaria. Eighty healthy controls (HC) who visited for routine health examination and physical checkups were recruited. Serum amyloid A and C-reactive protein levels were measured by automated methods.Results:
Serum amyloid A and C-reactive protein levels were significantly higher in AU (Serum amyloid A 207.1 (6.7-439.0) mg/L; C-reactive protein 16.0 (0.2-90.0) mg/L) and CU (Serum amyloid A 6.5 (2.5-35.8) mg/L; C-reactive protein 1.0 (0.1-16.0) mg/L) compared with HC (Serum amyloid A 5.04 (2.0-9.1) mg/L; C-reactive protein 1.2 (0.1-5.6) mg/L), and in AU compared with CU (all P<0.05). There were no differences between the CU and HC group. In CU, Serum amyloid A levels in those with moderate/severe urticaria (median, 16.4 (9.7-35.8) mg/L) were higher than in those with mild urticaria (median, 5.7 (2.5-9.5) mg/L) and HC (all P<0.05). Serum amyloid A and C-reactive protein levels exceeded the normal lab range in 90.7% and 72.1% patients with AU compared with 28.9% and 13.2% patients with CU, respectively. Significant positive correlations were found between serum amyloid A and C-reactive protein (r = 0.562, P < 0.001). Studylimitations:
There was no comparison between active disease and remission.Conclusion:
There was an association between serum amyloid A levels and urticaria. Higher serum amyloid A levels were associated with AU and more severe CU. Serum amyloid A may help to identify CU patients earlier.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Urticaria
/
Serum Amyloid A Protein
Type of study:
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2019
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
The Third People's Hospital of Hangzhou/CN
/
Zhejiang Province Traditional Chinese Medical Hospital/CN
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