BRAFV600E and KIT immunoexpression in early-stage melanoma
An. bras. dermatol
;
94(4): 458-460, July-Aug. 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1038300
ABSTRACT
Abstract Melanoma is widely known as the most lethal skin cancer. Specific tumor-related mortality can be significantly reduced if diagnosis and treatment are properly performed during initial phases of the disease. The current search for biomarkers in early-stage melanomas is a high-priority challenge for physicians and researchers. We aimed to assess the immunoexpression of BRAFV600E and KIT in a case series consisting of 44 early-stage melanomas. Formalin-fixed paraffin-embedded samples were systematically evaluated using a semi-quantitative method based on scores of percentage and intensity for immunostained tumor cells. We observed significant concordance between BRAFV600E and KIT immunoexpression in thin invasive melanomas. Our findings corroborate previous evidence showing abnormal expression of proteins associated with MAPK intracellular signaling pathway in early-stage melanomas.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Skin Neoplasms
/
Proto-Oncogene Proteins c-kit
/
Proto-Oncogene Proteins B-raf
/
Melanoma
Type of study:
Observational study
/
Risk factors
/
Screening study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de São Paulo/BR
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