Anticuerpos antitransglutaminasa tisular IgA y contra péptidos de gliadina desaminados IgG como predictores de enfermedad celíaca / IgA anti-tissue transglutaminase antibodies and IgG antibodies against deamidated gliadin peptides as predictors of celiac disease
Arch. argent. pediatr
;
117(1): 52-55, feb. 2019. tab
Article
in English, Spanish
| BINACIS, LILACS
| ID: biblio-1038450
RESUMEN
Objetivo. Comparar el rendimiento de anticuerpos antitransglutaminasa IgA (anti-TG2 IgA), antiendomisio IgA (EMA IgA) y antigliadina desaminada IgA/IgG (AGADGP IgA/IgG) para el diagnóstico de enfermedad celiaca. Métodos. Estudio descriptivo en pacientes con enfermedad celíaca. Se dosaron anticuerpos AGADGP (IgA/IgG), EMA IgA, anti-TG2 IgA y biopsia intestinal. Sexo mujeres (61 %). Mediana de edad 78,4 meses. Resultados. Se incluyeron 136 niños; 108 presentaron AGADGP IgA elevado; 124, AGADGP IgG aumentado; 128, EMA IgA positivo; 130, anti-TG2 IgA aumentado. Cuatro de 6 pacientes con anti-TG2 IgA negativos tenían AGADGP IgG elevado. La combinación de los anticuerpos AGADGP IgG + anti-TG2 IgA tuvo una correlación positiva en 134 pacientes y la combinación AGADGP IgG + EMA fue positiva en 133 niños. Conclusión. Se demostró la buena especificidad y sensibilidad de EMA IgA, anti-TG2 IgA y AGADGP IgG. La combinación AGADGP IgG/anti-TG2 mostró sensibilidad del 98-99 % y especificidad del 100 %. La elección de anti-TG2 y AGADGP IgG da excelentes resultados, con bajo costo y no depende del operador.
ABSTRACT
Objective. To compare the performance of IgA anti-tissue transglutaminase antibodies (IgA anti-tTG), IgA anti-endomysial antibodies (IgA EMA), and IgA/IgG antibodies against deamidated gliadin peptides (IgA/IgG anti-DGP) for the diagnosis of celiac disease. Methods. Descriptive study in patients with celiac disease. Anti-DGP (IgA/IgG), IgA EMA, IgA anti-tTG antibodies were measured and an intestinal biopsy was done. Sex female (61 %). Median age 78.4 months old. Results. A total of 136 children were included; 108 had high IgA anti-DGP titers; 124, increased IgG anti-DGP titers; 128, positive IgA EMA titers; and 130, increased IgA anti-tTG titers. High IgG anti-DGP titers were observed in 4/6 patients with negative IgA anti-tTG antibodies. The combination of IgG anti-DGP + IgA anti-tTG antibodies showed a positive correlation in 134 patients and the IgG anti-DGP + EMA combination was positive in 133 children. Conclusion. IgA EMA, IgA anti-tTG, and IgG anti-DGP antibodies exhibited an adequate specificity and sensitivity. The IgG anti-DGP/anti-tTG combination showed a 98-99 % sensitivity and a 100 % specificity. The anti-tTG and IgG anti-DGP option yields excellent results, with a low cost and independence from the observer.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Celiac Disease
/
Diagnosis
/
Antibodies
Type of study:
Diagnostic study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Humans
Language:
English
/
Spanish
Journal:
Arch. argent. pediatr
Journal subject:
Pediatrics
Year:
2019
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Hospital Nacional Alejandro Posadas/AR
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