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Can the genetic polymorphisms of the folate metabolism have an influence in the polycystic ovary syndrome?
Santos, Tayssia Beatriz dos; Paula, Helena Korres de; Balarin, Marly Aparecida Spadotto; Silva-Grecco, Roseane Lopes; Lima, Marco Fábio Prata; Resende, Elisabete Aparecida Mantovani Rodrigues de; Gomes, Mariana Kefalas Oliveira; Cintra, Mariangela Torreglosa Ruiz.
  • Santos, Tayssia Beatriz dos; Universidade Federal do Triângulo Mineiro. Uberaba. BR
  • Paula, Helena Korres de; Universidade Federal do Triângulo Mineiro. Uberaba. BR
  • Balarin, Marly Aparecida Spadotto; Universidade Federal do Triângulo Mineiro. Uberaba. BR
  • Silva-Grecco, Roseane Lopes; Universidade Federal do Triângulo Mineiro. Uberaba. BR
  • Lima, Marco Fábio Prata; Universidade Federal do Triângulo Mineiro. Uberaba. BR
  • Resende, Elisabete Aparecida Mantovani Rodrigues de; Universidade Federal do Triângulo Mineiro. Uberaba. BR
  • Gomes, Mariana Kefalas Oliveira; Universidade Federal do Triângulo Mineiro. Uberaba. BR
  • Cintra, Mariangela Torreglosa Ruiz; Universidade Federal do Triângulo Mineiro. Uberaba. BR
Arch. endocrinol. metab. (Online) ; 63(5): 501-508, Sept.-Oct. 2019. tab
Article in English | LILACS | ID: biblio-1038497
ABSTRACT
ABSTRACT Objective To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS). Subjects and methods This study included 203 women (99 women with PCOS and 104 controls). The genotyping was performed by PCR-RFLP. Chi-squared test and multiple logistic regression were used in the statistical analysis. Haplotype analysis was conducted using the SNPstat program. The results were presented in odds ratio (OR) and confidence interval of 95% (CI-95%), with a significance level of 5% (p ≤ 0.05). Results The genotypic distribution of the RFC-1 A80G polymorphism showed significant difference between the two groups, showing that the heterozygous genotype (AG genotype) was most frequent in controls. The polymorphic homozygous (GG genotype) of MTRR A66G polymorphism were most frequent in controls. The T-C haplotype MTHFR C677T and A1298C polymorphisms were more frequent in the control group (OR = 0.19; CI 95% — 0.04 to 0.93 e p = 0.042). The multivariate analysis evidenced that family history of PCOS was more frequent in the PCOS group (OR = 3.29; CI 95% — 1.48 to 7.31; p = 0.003). Conclusion In our casuistry, the polymorphic homozygous of MTRR A66G polymorphism gene and heterozygous of RFC-1 A80G polymorphism gene, the haplotype T-C C677T and A1298C polymorphisms of MTHFR gene, can be associated with protective factors for the disease.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polycystic Ovary Syndrome / Polymorphism, Genetic / Folic Acid Type of study: Etiology study / Observational study / Risk factors Limits: Adult / Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Triângulo Mineiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: Polycystic Ovary Syndrome / Polymorphism, Genetic / Folic Acid Type of study: Etiology study / Observational study / Risk factors Limits: Adult / Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Triângulo Mineiro/BR