Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age
Braz. j. infect. dis
;
21(5): 557-561, Sept.-Oct. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-1039204
ABSTRACT
Abstract Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4-16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State - Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibody levels. High frequency of IgM positivity strongly suggests active transmission of M. leprae in these communities. We suggest in the present work that salivary anti-PGL IgA and IgM are important biomarkers to be used for identifying communities with probable active transmission of M. leprae.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Glycolipids
/
Family
/
Contact Tracing
/
Leprosy, Multibacillary
/
Antibodies, Bacterial
/
Antigens, Bacterial
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Alagoas/BR
/
Universidade Federal do Ceará/BR
Similar
MEDLINE
...
LILACS
LIS