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Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age
Macedo, Alexandre Casimiro de; Cunha Jr, José Evandro; Yaochite, Juliana Navarro Ueda; Tavares, Clodis Maria; Nagao-Dias, Aparecida Tiemi.
  • Macedo, Alexandre Casimiro de; Universidade Federal do Ceará. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Fortaleza. BR
  • Cunha Jr, José Evandro; Universidade Federal do Ceará. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Fortaleza. BR
  • Yaochite, Juliana Navarro Ueda; Universidade Federal do Ceará. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Fortaleza. BR
  • Tavares, Clodis Maria; Universidade Federal de Alagoas. Faculdade de Enfermagem e Farmácia. Maceio. BR
  • Nagao-Dias, Aparecida Tiemi; Universidade Federal do Ceará. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Fortaleza. BR
Braz. j. infect. dis ; 21(5): 557-561, Sept.-Oct. 2017. tab, graf
Article in English | LILACS | ID: biblio-1039204
ABSTRACT
Abstract Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4-16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State - Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibody levels. High frequency of IgM positivity strongly suggests active transmission of M. leprae in these communities. We suggest in the present work that salivary anti-PGL IgA and IgM are important biomarkers to be used for identifying communities with probable active transmission of M. leprae.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Glycolipids / Family / Contact Tracing / Leprosy, Multibacillary / Antibodies, Bacterial / Antigens, Bacterial Type of study: Diagnostic study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Alagoas/BR / Universidade Federal do Ceará/BR

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Full text: Available Index: LILACS (Americas) Main subject: Glycolipids / Family / Contact Tracing / Leprosy, Multibacillary / Antibodies, Bacterial / Antigens, Bacterial Type of study: Diagnostic study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Alagoas/BR / Universidade Federal do Ceará/BR