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Interleukin-12 as a biomarker of the beneficial effects of food restriction in mice receiving high fat diet or high carbohydrate diet
de Almeida-Souza, C B; Antunes, M M; Godoy, G; Schamber, C R; Silva, M A R C P; Bazotte, R B.
  • de Almeida-Souza, C B; Universidade Estadual de Maringá. Departamento de Farmacologia e Terapêutica. Maringá. BR
  • Antunes, M M; Universidade Estadual de Maringá. Departamento de Farmacologia e Terapêutica. Maringá. BR
  • Godoy, G; Universidade Estadual de Maringá. Departamento de Farmacologia e Terapêutica. Maringá. BR
  • Schamber, C R; Universidade Estadual de Maringá. Departamento de Farmacologia e Terapêutica. Maringá. BR
  • Silva, M A R C P; Universidade Estadual de Maringá. Departamento de Farmacologia e Terapêutica. Maringá. BR
  • Bazotte, R B; Universidade Estadual de Maringá. Departamento de Farmacologia e Terapêutica. Maringá. BR
Braz. j. med. biol. res ; 51(12): e7900, 2018. tab
Article in English | LILACS | ID: biblio-1039240
ABSTRACT
The impact of food restriction (FR) during 56 days on serum levels of cytokines in mice fed a high-fat diet (HFD) or high-carbohydrate diet (HCD) were evaluated. The amount of food was reduced 50% for HFD-FR and HCD-FR groups compared to mice receiving free access to HFD (HFD group) or HCD (HCD group). We quantified the serum levels of basic fibroblast growth factor, granulocyte-macrophage colony-stimulating factor, inducible protein 10, interferon γ, interleukin 1α (IL-1α), IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, keratinocyte chemoattractant, macrophage inflammatory protein-1α, monocyte chemotactic protein 1, monokine induced by IFN-γ, and tumor necrosis factor α. Only IL-12 levels were lower (P<0.05), for both HFD-FR (HFD-FR vs HFD) and HCD-FR (HCD-FR vs HCD). Therefore, IL-12 levels could be considered a biological marker of the beneficial effects of FR.
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Full text: Available Index: LILACS (Americas) Main subject: Interleukin-12 / Caloric Restriction / Diet, High-Fat / Food Deprivation / Diet, Carbohydrate Loading / Animal Nutritional Physiological Phenomena Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Maringá/BR

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Full text: Available Index: LILACS (Americas) Main subject: Interleukin-12 / Caloric Restriction / Diet, High-Fat / Food Deprivation / Diet, Carbohydrate Loading / Animal Nutritional Physiological Phenomena Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Maringá/BR