Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury
Clinics
;
72(10): 645-648, Oct. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-1039533
ABSTRACT
OBJECTIVES:
Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal damage.METHODS:
We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein levels in the plasma of patients who underwent liver resection.RESULTS:
We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle maneuver is not performed.CONCLUSION:
We propose the use of insulin-like growth factor binding protein-1 as a novel biomarker of intestinal damage in such situations.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Venous Pressure
/
Insulin-Like Growth Factor Binding Protein 1
/
Hepatectomy
/
Intestinal Mucosa
/
Liver Neoplasms
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital Sírio-Libanês/BR
/
Universidade de São Paulo/BR
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