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Correlation between myocardial velocity measured using tissue doppler imaging in the left ventricular lead-implanted segment and response to cardiac resynchronization therapy
Yang, Dong-Mei; Yu, Fei; Chen, Kang-Yu; Su, Hao; Wang, Qi; Liu, Zhi-Quan; Hu, Kai; Xu, Jian; Yan, Ji.
  • Yang, Dong-Mei; First Affiliated Hospital of the University of Science and Technology of China. Division of Cardiology. Hefei. CN
  • Yu, Fei; First Affiliated Hospital of the University of Science and Technology of China. Division of Cardiology. Hefei. CN
  • Chen, Kang-Yu; First Affiliated Hospital of the University of Science and Technology of China. Division of Cardiology. Hefei. CN
  • Su, Hao; First Affiliated Hospital of the University of Science and Technology of China. Division of Cardiology. Hefei. CN
  • Wang, Qi; First Affiliated Hospital of the University of Science and Technology of China. Division of Cardiology. Hefei. CN
  • Liu, Zhi-Quan; First Affiliated Hospital of the University of Science and Technology of China. Division of Cardiology. Hefei. CN
  • Hu, Kai; First Affiliated Hospital of the University of Science and Technology of China. Division of Cardiology. Hefei. CN
  • Xu, Jian; First Affiliated Hospital of the University of Science and Technology of China. Division of Cardiology. Hefei. CN
  • Yan, Ji; First Affiliated Hospital of the University of Science and Technology of China. Division of Cardiology. Hefei. CN
Clinics ; 74: e1077, 2019. tab, graf
Article in English | LILACS | ID: biblio-1039556
ABSTRACT

OBJECTIVES:

This study investigated whether tissue Doppler imaging parameters, especially the peak systolic velocity of the left ventricular lead-implanted segment (Ss), affect cardiac resynchronization therapy response.

METHODS:

In this case-control study, 110 enrolled patients were divided into cases (responder group, n=65) and controls (nonresponder group, n=45) based on whether their left ventricular end-systolic volume was reduced by ≥15% at 6 months after surgery. Preoperative clinical and echocardiographic data were collected. Multivariate logistic regression models were used to analyze the factors affecting the response to cardiac resynchronization therapy, and receiver operating characteristic curves were plotted to evaluate their diagnostic values.

RESULTS:

The proportion of patients with left bundle branch block in the case group was higher than that in the control group. The control group showed a higher left atrial volume index, E/A ratio and E/Em ratio but lower Ss than that of the case group. A multivariate regression analysis showed that left bundle branch block, Ss, and an E/Em ratio>14 were independent risk factors affecting the response to cardiac resynchronization therapy. Ss=4.1 cm/s was the best diagnostic threshold according to the receiver operating characteristic curve.

CONCLUSIONS:

Ss is an important factor affecting the response to cardiac resynchronization therapy. Patients with heart failure associated with Ss<4.1 cm/s have a higher risk of nonresponse.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Echocardiography, Doppler / Cardiac Resynchronization Therapy / Heart Failure / Heart Ventricles Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: First Affiliated Hospital of the University of Science and Technology of China/CN

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Full text: Available Index: LILACS (Americas) Main subject: Echocardiography, Doppler / Cardiac Resynchronization Therapy / Heart Failure / Heart Ventricles Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: First Affiliated Hospital of the University of Science and Technology of China/CN