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Laryngeal Cancer Attributable Factors and the Influence on Survival Rates: A Single Brazilian Institution Experience
Innocentini, Lara Maria Alencar Ramos; Teixeira, Alisson Henrique; Casemiro, Luciana Assirati; Andrade, Matheus Carrijo; Ferrari, Tatiane Cristina; Ricz, Hilton Marcos Alves; Macedo, Leandro Dorigan de.
  • Innocentini, Lara Maria Alencar Ramos; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hospital das Clínicas. Ribeirão Preto. BR
  • Teixeira, Alisson Henrique; Universidade de Franca. Faculdade de Odontologia. Department of Oral Medicine. Franca. BR
  • Casemiro, Luciana Assirati; Universidade de Franca. Department of Oral Rehabilitation. Franca. BR
  • Andrade, Matheus Carrijo; Universidade de Franca. Faculdade de Odontologia. Department of Oral Medicine. Franca. BR
  • Ferrari, Tatiane Cristina; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hospital das Clínicas. Ribeirão Preto. BR
  • Ricz, Hilton Marcos Alves; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hospital das Clínicas. Ribeirão Preto. BR
  • Macedo, Leandro Dorigan de; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hospital das Clínicas. Ribeirão Preto. BR
Int. arch. otorhinolaryngol. (Impr.) ; 23(3): 299-304, July-Sept. 2019. tab, graf
Article in English | LILACS | ID: biblio-1040025
ABSTRACT
Abstract Introduction Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature. Objective To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx. Methods This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression. Results A total of 107 patients with a mean age of 59.8 years (range 19-81) were included in this study. Stages III and IV were associated with decreased DFS (p = 0.02) and OS (p = 0.02). Smoking patients had a greater period of disease evolution than non-smoking patients (p = 0.003). Alcohol consumption in smokers increased the risk of death by 2.8 (p = 0.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients (p = 0.04). Conclusion Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis.
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Full text: Available Index: LILACS (Americas) Main subject: Carcinoma, Squamous Cell / Laryngeal Neoplasms Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Int. arch. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Franca/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Carcinoma, Squamous Cell / Laryngeal Neoplasms Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Int. arch. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Franca/BR / Universidade de São Paulo/BR