Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus: implications for field studies
Mem. Inst. Oswaldo Cruz
;
112(3): 209-213, Mar. 2017. tab
Article
in English
| LILACS
| ID: biblio-1040567
ABSTRACT
Rapid tests (RTs) can be used as an alternative method for the conventional diagnosis of hepatitis B virus (HBV). This study aims to evaluate antibodies to HBsAg (anti-HBs) and antibodies to HBeAg (anti-HBe) RTs under different Brazilian settings. The following three groups were included GI viral hepatitis outpatient services; GII low resource areas; and GIII crack users and beauticians. Imuno-rápido anti-HBsAg™ and Imuno-rápido anti-HBeAg™ RTs were evaluated and showed specificities greater than 95% in all groups. The sensitivity values to anti-HBs were 50.38%, 51.05% and 46.73% and the sensitivity values to anti-HBe were 76.99%, 10.34% and 11.76% in the GI, GII and GIII groups, respectively. The assays had a low sensitivity and high specificity, which indicated their use for screening in regions endemic for HBV.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Hepatitis B virus
/
Hepatitis B
/
Hepatitis B Antibodies
/
Hepatitis B e Antigens
/
Hepatitis B Surface Antigens
Type of study:
Diagnostic study
Limits:
Adult
/
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Oswaldo Cruz-Fiocruz/BR
/
Hospital São Lucas/BR
/
Universidade Federal do Mato Grosso do Sul/BR
/
Universidade Federal do Rio de Janeiro/BR
/
Universidade Federal do Tocantins/BR
/
Universidade de Brasília/BR
Similar
MEDLINE
...
LILACS
LIS