The use of circulating cathodic antigen rapid test and serology for diagnosis of active Schistosoma mansoni infection in migrants in Italy, a non-endemic country: a cross sectional study
Mem. Inst. Oswaldo Cruz
;
112(6): 452-455, June 2017. tab
Article
in English
| LILACS
| ID: biblio-1040569
ABSTRACT
ABSTRACT Diagnosis of schistosomiasis in migrants coming from endemic areas can be difficult, especially in asymptomatic subjects. Light-intensity disease, in fact, may be missed due to the low sensitivity of the stool microscopy and serologic testing cannot distinguish between a resolved infection and an active infection in patients who have been infected and treated in the past, because specific antibodies can persist despite cure. We describe a cross-sectional study conducted on 82 migrants tested for Schistosoma mansoni on single blood (anti-schistosome antibodies, total IgE) and urine [point-of-care (POC) circulating-cathodic-antigen (CCA) test] samples. A positive POC-CCA test (active infection) resulted in two untreated patients with a positive serology while all patients (n = 66) with a past infection showed a negative POC-CCA test. POC-CCA urine test in combination with serology may be helpful in rapidly differentiate active from past S. mansoni infection in migrants coming from endemic areas.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Schistosoma mansoni
/
Transients and Migrants
/
Schistosomiasis mansoni
/
Antigens, Helminth
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Animals
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2017
Type:
Article
Affiliation country:
Central African Republic
/
Italy
Institution/Affiliation country:
San Raffaele Scientific Institute/IT
/
Society of Priests of the Sacred Heart of Betharram/CF
Similar
MEDLINE
...
LILACS
LIS